Science Portrait: Professor Masahiko Hibi

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Prof. Masahiko Hibi, M.D., Ph.D., Graduate School of Science, Nagoya University

 

This is a summary of the curriculum vitae (CV) of Prof. Masahiko Hibi, M.D., Ph.D., Graduate School of Science, Nagoya University, Nagoya, Japan.

Professor Hibi is a world-renowned scientist studying zebrafish neuroscience, with the development and function of the cerebellum being one of his major topics. His work has been cited  over 30,000 times (Google Scholar).

After, in 1988, obtaining his MD from Hiroshima University, School of Medicine, he pursued his Ph.D. studies in the lab of the famous Professor Tadamitsu Kishimoto at Osaka University. Here, he participated in what probably is among the top five studies that Japanese Immunology science is famous for, namely the elucidation of interleukin 6 (IL-6) functions and mechanisms. As a first author, Professor Hibi identified gp130, which is part of the IL-6 receptor complex (Hibi et al, Cell 1990). Inhibiting IL-6 function is of significant medical importance, as treatment with “tocilizumab” (developed by the same research group) ameliorates inflammations like rheumatoid arthritis and may also benefit anti-cancer therapy.

In 1992-1995, while a postdoc in San Diego at the University of California, Professor Hibi worked on signal transduction (intracellular phosphorylation cascades) and the transcription factor C-Jun under Dr. Michael Karin. This also resulted in several top articles, including Nature and Cell (3x). One of them, on the kinase JNK, has over 4,000 citations (Dérijard et al., Cell 1994)!

He then returned to Osaka University, where he would work until 2001 and eventually become an Associate Professor.  During this period, a major focus was applying what he had learned in the US, and unraveling intracellular IL-6 signaling cascades. This period again resulted in major publications, including in Journal of Experimental Medicine, Immunity (2x), and EMBO Journal (4x). Towards the end of this period, he started to use zebrafish, and this has been his major model system ever since.

After Osaka, he worked until 2009 in Kobe, both at Kobe University and the RIKEN Center for Developmental Biology, and from 2009 he became Professor at Nagoya University. He kept publishing top articles on zebrafish such as in Nature Cell Biology , Nature Neuroscience, Nature Communications, and PNAS (2x). His work on zebrafish development gradually became more focused on neuroscience, in particular on the cerebellum and Purkinje cells.

I know Professor Hibi as a very kind person, and remember with gratitude that he offered me to use his zebrafish research facilities (an offer that unfortunately I could not take up on). I also remember him as explaining very well, so I am sure he will give a great lecture to Fujita University.

It is a great pleasure and honor that such a renowned scientist will give us a presentation.

 

CURRICULUM VITAE

 

Education:

1988  M.D., Hiroshima University, School of Medicine,

1992  Ph.D., Osaka University, Graduate School of Medicine

 

Professional Experience:

1988-1992   Graduate Student (Supervisor: Dr. Tadamitsu Kishimoto)

Institute for Molecular and Cellular Biology, Osaka University

1992-1995   Postdoctoral Fellow (Supervisor: Dr. Michael Karin)

Department of Pharmacology, University of California, San Diego

1995-1999   Assistant Professor

Division of Molecular Oncology, Osaka University Medical School

1999-2001   Associate Professor

Division of Molecular Oncology, Osaka University Graduate School of Medicine

2001-2009   Team Leader

Laboratory for Vertebrate Axis Formation, RIKEN Center for Developmental Biology

2002-2009   Adjunct Professor

Kobe University Graduate School of Medicine

2009-2010   Adjunct Team Leader

RIKEN Center for Developmental Biology

2009-2019   Professor

Bioscience and Biotechnology Center, Nagoya University

2019-            Professor

Graduate School of Science, Nagoya University

 

Websites:

http://bbc.agr.nagoya-u.ac.jp/~junkei/new/index_en.html

https://www.bio.nagoya-u.ac.jp/research/

https://scholar.google.co.jp/citations?user=suIqWOkAAAAJ&hl=ja&oi=ao

 

 

PUBLICATIONS

Original Papers

    1. Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., and Kishimoto, T.* (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58, 573-581.
    2. Hirata, Y., Taga, T., Hibi, M., Nakano, N., Hirano, T., and Kishimoto, T.* (1989) Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies. J. Immunol. 143, 2900-2906.
    3. Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., and Kishimoto, T.* (1989) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63, 1149-1157.
    4. Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T., and Kishimoto, T.* (1991) Critical cytoplasmic region of the interleukin-6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. 88, 11349-11353.
    5. Saito, M., Yoshida, K., Hibi, M., Taga, T., and Kishimoto, T.* (1992) Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J. Immunol. 148, 4066-4071.
    6. Falus, A., Taga, T., Hibi, M., Murakami, M., and Kishimoto, T.* (1992) Regulation of IL-6 receptor and gp130 expression on human cell lines of lymphoid and myeloid origin. Cytokine 4, 495-499.
    7. Murakami, M., Hibi, M., Nakagawa, N., Nakagawa, T., Yasukawa, K., Yamanishi, K., Taga, T., and Kishimoto, T.* (1993) IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260, 1808-1810.
    8. Yawata, H., Yasukawa, K., Natsuka, S., Mirakami, M., Yamasaki, K., Hibi, M., Taga, T., and Kishimoto, T.* (1993) Structure- function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6 binding and for IL-6 signal transduction through gp130. EMBO J. 12, 1705-1712.
    9. Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M.* (1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148.
    10. Derijard, B., Hibi, M., Wu, I-H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R.J.* (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.
    11. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y.* (1994) JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77, 727-736.
    12. Westwick, J.K., Cox, A.D., Der, C.J., Cobb, M.H., Hibi, M., Karin, M. and Brennerl, D.A.* Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc. Natl. Acad. Sci. 91, 6030-6034.
    13. Smeal, T., Hibi, M., and Karin, M.* (1994) Altering the specificity of signal transduction cascades: positive regulation of c-Jun trans criptional activity by protein kinase A. EMBO J. 13, 6006-6010.
    14. Mochizuki, N., Hibi, M., Kanai, Y., and Insel, P.A.* (1995) Interaction of the protein nucleobindin with Gai2, as revealed by the yeast two-hybrid system. FEBS Letters 373, 155-158.
    15. Yamanaka, Y., Nakajima, K., Fukada, T., Hibi, M., and Hirano, T.* (1996) Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO J. 15, 1557-1565.
    16. Nakajima, K., Yamanaka, Y., Nakae, H., Kojima, H., Kiuchi, N., Ichiba, M., Kitaoka, T., Fukada, T., Hibi, M., and Hirano, T.* (1996) A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 15, 3651-3658.
    17. Claret, F-X., Hibi, M., Dhut, S., Toda, T., and Karin, M.* (1996) Jun activation domain binding proteins: a new group of conserved coactivators that increase the specificity of AP-1 factors. Nature 383, 453-457.
    18. Kallunki, T., Deng, T., Hibi, M., and Karin, M.* (1996) c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87, 929-939.
    19. Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., and Hirano, T.* (1996) Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5, 449-460.
    20. Fujitani, Y., Hibi, M., Fukada, T., Takahashi-Tezuka, M., Yoshida, H., Yamaguchi, T., Sugiyama, K., Yamanaka, Y., Nakajima, K., and Hirano, T.* (1997) An alternative pathway for STAT activation that is mediated by direct interaction of JAK and STAT. Oncogene 14, 751-761.
    21. Qin, S., Minami, Y., Hibi, M., Kurosaki, T., and Yamamura, H.* (1997) Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress. J. Biol. Chem. 272, 2098-2103.
    22. Takahashi-Tezuka, M., Hibi, M., Fujitani, Y., Fukada, T., Yamaguchi, T., and Hirano, T.* (1997) Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Oncogene 14, 2273-2282.
    23. Lee, IS., Liu, Y., Narazaki, M., Hibi, M., Kishimoto, T., and Taga, T.* (1997) Vav is associated with signal transducing molecules gp130, Grb2, and Erk2, and is tyrosine phosphorylated in response to interleukin-6. FEBS-Lett. 401, 133-137.
    24. Hara, T., Murakami, M., Maeda, H., Hibi, M., and Uede T.* (1997) Involvement of a common 10-amino-acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses. Biochem. Biophys. Res. Comm. 233, 187-192.
    25. Ihara, S., Nakajima, K., Fukada, T., Hibi, M., Nagata, S., Hirano, T., and Fukui, Y.* (1997) Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. EMBO J. 16, 5345-5352.
    26. Kim, C-H., Bae, Y-K., Yamanaka, Y., Yamashita, S., Shimizu, T., Fujii, R., Park, H-C., Yeo, S-Y., Huh, T-L., Hibi, M., and Hirano, T.* (1997) Overexpression of neurogenin induces ectopic expression of HuC in zebrafish. Neurosci. Lett. 239, 113-116.
    27. Yamanaka, Y., Mizuno, T., Sasai, Y., Kishi, M., Takeda, H., Kim, C-H., Hibi, M., and Hirano, T.* (1998) A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Genes Dev. 12, 2345-2353.
    28. Takahashi-Tezuka, M., Yoshida, Y., Fukada, T., Ohtani, T., Yamanaka, Y., Nishida, K., Nakajima, K., Hibi, M., and Hirano, T.* (1998) Gab1 acts as an adaptor molecule linking the cytokine receptor gp130 to ERK Mitogen-Activated Protein Kinase. Mol. Cell. Biol. 18, 4109-4117.
    29. Fukada, T., Ohtani, T., Yoshida, Y., Shirogane, T., Nishida, K., Nakajima, K., Hibi, M., and Hirano, T.* (1998) STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition. EMBO J. 17, 6670-6677.
    30. Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., and Hirano, T.* (1999) STAT3 is required for the gp130-mediated full activation of the c-myc J. Exp. Med. 189, 63-73.
    31. Nishida, K., Yoshida, Y., Itoh, M., Fukada, T., Ohtani, T., Shirogane, T., Atsumi, T., Takahashi-Tezuka, M., Ishihara, K., Hibi, M., and Hirano, T.* (1999) Gab family adapter proteins act downstream of cytokine and growth factor receptors, and T and B cell antigen receptors. Blood 93, 1809-1816.
    32. Fekany, K., Yamanaka, Y., Leung, T., Sirotkin, H. I., Topczewski, J., Gates, M. A., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A. F., Driever, W., Hirano, T., Talbot, W. S., and Solnica-Krezel, L.* (1999) The zebrafish bozozok locus encodes Dharma, a hemoedomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development 126, 1427-1438.
    33. Wickrema, A., Uddin, S., Sharma, A., Chen, F., Alsayed, Y., Ahmad, S., Sawyer, S.T., Krystal, G., Yi, T., Nishada, K., Hibi, M., Hirano, T., and Platanias. L.C.* (1999) Engagement of gab1 and gab2 in erythropoietin signaling. J. Biol. Chem. 274, 24469-24474.
    34. Nakayama, K., Hara, T., Hibi, M., Hirano, T., and Miyajima, A.* (1999) A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth. J. Biol. Chem. 274, 24766-24772.
    35. Ito, M., Yoshioka, K.*, Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., and Yamamoto, K-i. (1999) JSAP1, a novel JNK-binding protein that functions as a scaffolding factor in the JNK signaling pathway. Mol. Cell. Biol. 19, 7539-7548,.
    36. Shirogane, T., Fukada, T., Muller, J.M.M., Shima, D.T., Hibi, M., and Hirano, T*. (1999) Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and anti-apoptosis. Immunity 11, 709-719.
    37. Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., and Hirano, T.* (2000) Zebrafish Dkk1 functions in Forebrain Specification and Axial Mesendoderm Formation. Dev. Biol. 217, 138-152.
    38. Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., Itoh, M., Okano, H., Hibi, M., and Hirano, T.* (2000) Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12, 95-105.
    39. Shimizu, T., Yamanaka, Y., Ryu, S-L., Hashimoto, H., Yabe, T., Hirata, T., Bae, Y-K., Hibi, M., and Hirano, T.* (2000) Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish. Mech. Dev. 91, 293-303.
    40. Daino, H., Matsumura, I., Takeda, K., Oajima, J., Tanaka, H., Ueda, S., Shibayama, H., Ikeda, H., Hibi, M., Hirano, T., and Kanakura, Y.* (2000) Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleuikin 6-dependent hematopoietic cells. Blood 95, 2577-2585.
    41. Itoh, M., Yoshida, Y., Nishida, K., Narimatsu, M., Hibi, M., and Hirano, T.* (2000) A role of Gab1 for heart, placenta, and skin development, and growth factors- and cytokines-induced ERK MAP kinase activation. Mol. Cell. Biol. 20, 3695-3704.
    42. Hirata, T., Yamanaka, Y., Ryu, S.-L., Shimizu, T., Yabe, T., Hibi, M., and Hirano, T.* (2000) Novel mix-family homeobox genes in zebrafish and their differential regulation. Biochem. Biophys. Res. Commun. 271, 603-609.
    43. Hashimoto H., Yabe, T., Hirata, T., Shimizu, T., Bae, Y.-K., Yamanaka, Y., Hirano, T., and Hibi, M.* (2000) Expression of the zinc finger gene fez-like in zebrafish forebrain. Mech. Dev. 97, 191-195.
    44. Fujii, R., Yamashita, S., Hibi, M., and Hirano, T.* (2000) Asymmetric p38 activation in zebrafish; its possible role in symmetric and synchrnous cleavage. J. Cell. Biol. 150, 1335-1347.
    45. Park, H-C., Kim, C-H., Bae, Y-K., Yeo, S-Y., Kim, S-H., Hong, S-K., Shin, J., Hibi, M., Hirano, T., Miki, N., Chitnis, A.B., and Huh, T-L.* (2000) Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons. Dev. Biol. 227, 279-293.
    46. Muraoka, O., Ichikawa, H., Shi, H., Okamura, S., Taira, E., Higuchi, H., Hirano, T., Hibi, M., and Miki, N.* (2000) Kheper, a novel ZFH/EF1 family, regulates the development of the neuroectoderm of zebrafish (Danio rerio). Dev. Biol. 228, 29-40.
    47. Ryu, S-L., Fujii, R., Yamanaka, Y., Shimizu, T., Yabe, T., Hirata, T., Hibi, M., and Hirano, T.* (2001) Regulation of dharma/bozozok by the Wnt pathway. Dev. Biol. 231, 397-409.
    48. Mizuno, K., Shirogane, T., Shinohara, A., Iwamatsu, A., Hibi, M., and Hirano, T.* (2001) Regulation of Pim-1 by Hsp90. Biochem Biophys Res Commun. 281, 663-669.
    49. Kojima, H., Shinagawa, A., Shimizu, S., Kanada, H., Hibi, M., Hirano, T., and Nagasawa, T.* (2001) Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function. Exp Hematol. 29, 616-622.
    50. Narimatsu, M., Maeda, H., Itoh, S., Atsumi, T., Ohtani, T., Nishida, K., Itoh, M., Kamimura, D., Park, SJ., Mizuno, K., Miyazaki, Ji., Hibi, M., Ishihara, K., Nakajima, K., and Hirano, T.* (2001) Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells. Mol Cell Biol. 21, 6615-6625.
    51. Yamasaki, S., Nishida, K., Hibi, M., Sakuma, M., Shiina, R., Takeuchi, A., Ohnishi, H., Hirano, T., and Saito, T.* (2001) Docking protein Gab2 is phosphorylated by ZAP70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. J. Biol. Chem. 276, 45175-45183.
    52. Yamada, K., Nishida, K., Hibi, M., Hirano, T., and Matsuda, Y.* (2001) Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse, and rat. Cytogenet Cell Genet. 94, 39-42.
    53. Nishida, K., Wang, L., Mori, E., Park, S-J., Narimatsu, M., Itoh, S., Yamasaki, S., Fujishima, M., Ishihara, K., Hibi, M., Kitamura, Y., and Hirano, T.* (2002) Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling. Blood 99,1866-1869.
    54. Itoh, S., Itoh, M., Nishida, K., Yamasaki, S., Yoshida, Y., Narimatsu, M., Park, J.P., Hibi, M., Ishihara, K., and Hirano, T.* (2002) Adapter molecule Grb2-associated binder 1 is specifically expressed in marginal zone B cells and negatively regulates thymus-independent antigen-2 responses. Immunol. 168, 5110-5116.
    55. Shimizu, T., Yamanaka, Y., Nojima, H., Yabe, T., Hibi, M., and Hirano, T.* (2002) A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Mech. Dev. 118, 125-138.
    56. Levkowitz, G., Zeller, J., Sirotkin, H.I., French, D., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A.* (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nat. Neurosci. 6, 28-33.
    57. Yamasaki, S., Nishida, K., Yoshida, Y., Itoh, M., Hibi, M., and Hirano, T.* (2003) Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. Oncogene 22, 1546-1556.
    58. Bae, Y.-K., Shimizu, T., Yabe, T., Kim, C.-H., Hirata, T., Nojima, H., Muraoka, O., Hirano, T., and Hibi, M.* (2003) A homeobobi x gene, pnx, is involved in the formation of posterior neurons in zebrafish. Development 130, 1853-1865.
    59. Yabe, T., Shimizu, T., Muraoka, O., Bae, Y.-K., Hirata, T., Nojima, H., Kawakami, A., Hirano, T., and Hibi, M.* (2003) Ogon/Secreted Frizzled functions as a negative feedback regulator of BMP signaling. Development 130, 2705-2716.
    60. Bae, Y.-K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., and Hibi, M.* (2004) Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene Expr. Patterns 4, 481-486.
    61. Hashimoto, H., Rebagliati, M., Ahmad, N., Muraoka, O., Kurokawa, T., Hibi, M.* and Suzuki, T.* (2004) The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. Development 131, 1741-1753.
    62. Hirata, T., Suda, Y., Nakao, K., Narimatsu, M., Hirano, T., and Hibi, M.* (2004) The zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons. Dev. Dyn. 230, 546-556.
    63. Nojima, H., Shimizu, T. *, Kim, C.-H., Yabe, T., Bae, Y.-K., Muraoka, O., Hirata, T., Chitnis, A., Hirano, T., and Hibi, M.* (2004) Genetic evidence for involvement of maternally derived Wnt canonical pathway in dorsal determination in zebrafish. Mech. Dev. 121, 371-386.
    64. Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., and Aizawa, S. (2005) Shisa promotes head formation through the inhibition of receptor maturation for the caudalizing factors, Wnt and FGF. Cell 120, 223-235.
    65. Shimizu, T., Bae, Y.-K., Muraoka, O., and Hibi, M.* (2005) Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev. Biol. 279, 125-141.
    66. Bae, Y-K., Shimizu, T., and Hibi, M.* (2005) Patterning of proneuronal and inter-proneuronal domains by hairy– and enhancer of split-related genes in zebrafish neuroectoderm. Development 132, 1375-1385.
    67. Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.-K., Nojima, H., and Hibi, M.* (2005) E-cadherin is required for gastrulation cell movements in zebrafish. Mech. Dev. 122, 747-763.
    68. Molyneaux, B.J., Arlotta, P., Hirata, T., Hibi, M., and Macklis J.D.* (2005) Fezl is required for the birth and specification of corticospinal motor neurons. Neuron 47, 817-831.
    69. Hirata, T., Nakazawa, M., Yoshihara, S., Miyachi, H., Kitamura, K., Yoshihara, Y., and Hibi, M.* (2006) Zinc-finger gene Fez in the olfactory neurons regulates development of the olfactory bulb non-cell-autonomously. Development 133, 1433-1443.
    70. Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y-K., Hashimoto, H., and Hibi, M.* (2006) Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Nat. Cell Biol. 8, 329-340.
    71. Hirata, T., Nakazawa, M., Muraoka, O., Nakayama, R., Suda, Y., and Hibi, M.* (2006) Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Development 133, 3993-4004.
    72. Shimizu, T., Bae, Y.-K., and Hibi, M.* (2006) Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Development 133, 4709-4719.
    73. Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y., and Yamasu, K.* (2007) Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal. Dev. Dyn. 236, 564-571.
    74. Komuta, Y., Hibi, M., Arai, T., Nakamura, S., and Kawano, H.* (2007) Defects in reciprocal projects between the thalamus and cerebral cortex in the early development of Fezl-deficient mice. J. Comp. Neurol. 503, 454-465.
    75. Katsuyama, Y., Oomiya, Y., Dekimoto, H., Motooka, E., Takano, A., Kikkawa, S., Hibi, M., and Terashima, T.* (2007) Expression of zebrafish ROR alpha gene in cerebellar-like structures. Dev. Dyn. 236, 2694-2701.
    76. Asakawa, K., Suster, M. L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A., Kishimoto, Y., Hibi, M., and Kawakami, K.* (2008) Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish. Proc. Natl. Acad. Sci. USA. 105, 1255-1260.
    77. Kim, H., Kim, S., Chung, A.Y., Bae, Y.K., Hibi, M., Lim, C.S., and Park, H.C.* (2008) Notch-regulated perineurium development from zebrafish spinal cord. Neurosci. Lett. 448, 240-244.
    78. Bae, Y.-K., Kani, S., Shimizu, T., Tanabe, K., Nojima, H., Kimura, Y., Higashijima, S.-I., and Hibi, M.* (2009) Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Dev. Biol. 330, 406-426.
    79. Nojima, H., Rothhämel, S., Shimizu, T., Kim, C.H., Yonemura, S., Marlow, F.L., Hibi, M.* (2010) Syntabulin, a motor protein linker, controls dorsal determination. Development 137, 923-933.
    80. Shimizu, T., Nakazawa, M., Kani, S., Bae, Y.-K., Shimizu, T., Kageyama, R., Hibi, M.* (2010) Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in forebrain. Development 137, 1875-1885.
    81. Kani, S., Bae, Y.-K., Shimizu, T., Tanabe, K., Satou, C., Parsons, M.J. Scott, E., Higashijima, S.-I., and Hibi, M.* (2010) Proneural gene-linked neurogenesis in zebrafish cerebellum. Dev. Biol. 343, 1-17.
    82. Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y.* (2010) Expression of strawberry notch family genes during zebrafish embryogenesis. Dev.Dyn. 239, 1789-1796.
    83. Nagao, Y., Cheng, J., Kamura, K., Seki, R., Maeda, A., Nihei, D., Koshida, S., Wakamatsu, Y., Fujimoto, T., Hibi, M., and Hashimoto, H.* (2010) Dynein axonemal intermediate chain 2 is required for formation of the left-right body axis and kidney in medaka. Dev. Biol. 347, 53-61.
    84. Tanabe, K., Kani, S., Shimizu, T., Bae, Y.-K., Abe, T., and Hibi, M.* (2010) Atypical PKC regulates primary dendrite specification of cerebellar Purkinje cells by localizing Golgi apparatus. J. Neurosci. 30, 16983-16992.
    85. Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y.* (2011) Function of strawberry notch family genes in the zebrafish brain development. Kobe J. Med. Sci. 56, E220-E230.
    86. Imai, H., Oomiya, Y., Kikkawa, S., Shoji, W., Hibi, M., Terashima, T., and Katsuyama, Y.* (2012) Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period. Dev. Growth Differ. 54, 253-263.
    87. Moriyama, Y., Kawanishi, T., Nakamura, R., Tsukahara, T., Sumiyama, K., Suster, M.L., Kawakami, K., Toyoda, A., Fujiyama, A., Yasuoka, Y., Nagao, Y., Sawatari, E., Shimizu, A., Wakamatsu, Y., Hibi, M., Taira, M., Okabe, M., Naruse, K., Hashimoto, H., Shimada, A., and Takeda, H.* (2012) The Medaka zic1/zic4 Mutant Provides Molecular Insights into Teleost Caudal Fin Evolution. Curr. Biol. 22, 601-601.
    88. Kuscha, V., Fraser, S.L., Dias, T.B., Hibi, M., Becker, T., and Becker, C.G.* (2012) Lesion-induced generation of interneuron cell types in specific dorso-ventral domains in the spinal cord of adult zebrafish. J. Comp. Neurol. 520, 3604-3616.
    89. Tran, L.D., Hino, H., Quach, H., Lim S., Shindo, A., Mimori-Kiyosue, Y., Mione, M., Ueno, N., Winkler, C., Hibi, M., Sampath, K.* (2012) Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish. Development 139, 3644-3652.
    90. Yaniscostas, C., Barbieri, E., Hibi, M., Brice, A., Stevanin, G., and Soussi-Yaniscostas, N.* (2012) Requirement for zebrafish ataxin7 in differentiation of photoreceptors and cerebellar neurons. PLoS One 7, e50705.
    91. Kwon, HB., Fukuhara, S., Asakawa, K., Ando, K., Kashiwada, T., Kawakami, K., Hibi, M., Kwon, YG., Kim, KW., Alitalo, K., and Mochizuki, N.* (2013) The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish. Development 140, 408104090.
    92. Nagao, Y., Suzuki, T., Shimizu, A., Kimura, T., Seki, R., Adachi, T., Inoue, C., Omae, Y., Kamei, Y., Hara, I., Taniguchi, Y., Naruse, K., Wakamatsu, Y., Kelsh, RN., Hibi, M., and Hashimoto H.* (2014) Sox5 functions as a fate switch in medaka pigment cell development. PLoS Genet. 10, e1004246.
    93. Takeuchi, M., Matsuda, K., Yamaguchi, S., Asakawa K, Miyasaka, N, Lal, P., Yoshihara, Y., Koga, A., Kawakami, K., Shimizu, T., and Hibi, M.* (2015) Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry. Dev. Biol. 397, 1-17.
    94. Takeuchi, M., Yamaguchi, S., Yonemura, S., Kakiguchi, K., Sato, Y., Higashiyama, T., Shimizu, T., and Hibi, M.* (2015) Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. PLoS Genet. 11, e1005587.
    95. Kim, J.D., Park, K.E., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M., Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., and Fukamizu, A.* (2015) PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination. Sci. Adv. 1, e1500615.
    96. Scalise, K., Shimizu, T., Hibi, M., and Sawatell, N.B.* (2016) Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish. J. Neurophysiol. 116, 2067-2080.
    97. Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., and Hibi, M.* (2017) Gene expression profiling of granule cells and Purkinje cells in zebrafish cerebellum. J. Comp. Neurol. 525, 1558-1585.
    98. Chiba, A., Watanabe-Takano, H., Terai, K., Fukui, H., Miyazaki, T., Uemura, M., Hashimoto, H. Hibi, M., Fukuhara, S., and Mochizuki, N.* (2017) Osteorin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish. Development 144, 334-344.
    99. Song, KH. Woo, SR., Chung, JY., Lee, HJ., Oh, SJ., Hong, SO., Shim, J., Kim, YN., Rho, SB., Hong, SM., Cho, H., Hibi, M., Bae, DJ., Kim, SY., Kim, MG., Kim, TW., and Bae, YK.* (2017) REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. Cell Death Dis. 8, e2536.
    100. Yun, UJ., Sung, JY., Park, SY., Ye, SK., Shim, J., Lee, JS., Hibi, M., Bae, YK., and Kim, YN*. (2017) Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway. Cell Death Dis. 8, e2621.
    101. Takeuchi, M., Inoue, C., Goshima, A., Nagao, Y., Shimizu, K., Miyamoto, H., Shimizu, T., Hashimoto, H., Yonemura, S., Kawahara, A., Hirata, Y., Yoshida, M., and Hibi, M.* (2017) Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Genes Cell. 22, 723-741.
    102. Matsuda, K., Yoshida, M., Kawakami, K., Hibi, M.*, and Shimizu, T. (2017) Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum. Sci Rep. 7, 11865.
    103. Hino, H., Nakanishi, A., Seki, R., Aoki, T., Yamaha, E., Kawahara, A., Shimizu, T., and Hibi, M.* (2018) Roles of maternal wnt8a transcripts in axis formation in zebrafish. Dev Biol. 434, 96-107.
    104. Kidwell, CU., Su, CY., Hibi, M., and Moens, CB.* (2018) Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum. Dev Biol. 438, 44-56.
    105. Nagao, Y., Takada, H., Miyadai, M., Adachi, T., Seki, R., Kamei, Y., Hara, I., Taniguchi, Y., Naruse, K., Hibi, M., Kelsh, RN., and Hashimoto, H.* (2018) Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish. PLoS Genet. 14, e1007260.
    106. Hara, Y., Takeuchi, M., Kageyama, Y., Tatsumi, K., Hibi, M., Kiyonari, H., and Kuraku, S.* (2018) Madagascar ground gecko genome analysis characterizes asymmetric fates of duplicated genes. BMC Biol. 16, 40.
    107. Wada, S., Shen, B., Kawano-Yamashita, E., Nagata, T., Hibi, M., Tomatsu, S., Koyanagi, M., and Terakita, A.* (2018) Color opponency with a single kind of bistable opsin in the zebrafish pineal organ. Proc Natl Acad USA. 115, 11310-11315.
    108. Dohaku, R., Yamaguchi, M., Yamamoto, N., Shimizu, T., Osakada, F., and Hibi, M.* (2019) Tracing of Afferent Connections in the Zebrafish Cerebellum Using Recombinant Rabies Virus. Front Neural Circuits. 13, 30. doi: 10.3389/fncir.2019.00030.
    109. Nimura, T., Itoh, T., Hagio, H., Hayashi, T., Di Donato, V., Takeuchi, M., Itoh, T., Inoguchi, F., Sato, Y., Yamamoto, N., Katsuyama, Y., Del Bene, F., Shimizu, T., and Hibi, M.* (2019) Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish Dev Biol. 455, 393-408. doi: 10.1016/j.ydbio.2019.07.010.
    110. Verreet, T., Weaver, CJ., Hino, H., Hibi, M., and Poulain, FE.* (2019) Syntaphilin-Mediated Docking of Mitochondria at the Growth Cone Is Dispensable for Axon Elongation In Vivo. eNeuro 6, ENEURO.0026-19.2019. doi: 10.1523/ENEURO.0026-19.2019.
    111. Sugiura, M., Tsunoda, SP., Hibi, M., and Kandori, H.* (2020) Molecular Properties of New Enzyme Rhodopsins with Phosphodiesterase Activity. ACS Omega. 5, 10602-10609.
    112. Chang, W., Pderoni, A., Hohendorf, V., Giacomello, S., Hibi, M., Köster, RW., and Ampatzis, K.* (2020) Functional distinct Purkinje cell types show temporal precision in encoding locomotion. Proc Natl Acad Sci USA. 117, 17330-17337.
    113. Itoh, T., Takeuchi, M., Sakagami, M., Asakawa, K., Sumiyama, K., Kawakami, K., Shimizu, T., and Hibi, M.* (2020) Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Development. 147, dev190603. doi: 10.1242/dev/190603.
    114. Koyama, W., Hosomi, R., Matsuda, K., Kawakami, K., Hibi, M.*, and Shimizu T.* (2021) Involvement of Cerebellar Neural Circuits in Active Avoidance Conditioning in Zebrafish. eNeuro. 8, ENEURO.0507-20.2021. doi: 10.1523/ENEURO.0507-20.2021.
    115. Itoh, T., Inoue, S., Sun, X., Kusuda, R., Hibi, M.*, and Shimizu, T.* (2021) Cfdp1 controls the cell cycle and neural differentiation in the zebrafish cerebellum and retina. Dev Dyn. 250, 1618-1633. doi: 10.1002/dvdy.371.
    116. Tsunogai, Y., Miyadai, M., Nagao, Y., Sugiwaka, K., Kelsh R.N., Hibi, M., and Hashimoto, H.* (2021) Contribution of sox9b to pigment cell formation in medaka fish. Dev Growth Differ. 63, 516-522.doi: 10.1111/dgd.12760.
    117. Ikenaga, T.,* Shimomai, R., Hagio, H., Kimura, S., Matsumoto, K., Kato, D.-I., Uesugi, K., Takeuchi, A., Yamamoto, N., and Hibi, M. (2021) Morphological analysis of the cerebellum and its efferent system in a basal actinopterygian fish, Polypterus senegalus. J Comp Neurol. doi: 10.1002/cne.25271.
    118. Kim, J., Hyun, M., Hibi, M., and You, Y.-J.* (2021) Maintenance of quiescent oocytes by noradrenergic signals. Nat Commun. 12, doi: 10.1038/s41467-021-26945-x.
    119. Wu, D., Arakawa, H., Fujita, A., Hashimoto, H., Hibi, M., Naruse, K., Kamei, Y., Sato. C., and Kitajima, K.* (2021) A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to protein insolubility. Sci Rep 11, 23211. doi: 10.1038/s41598-021-01715-3.
    120. Hagio, H., Koyama, W., Hosaka, S., Song, A.D., Narantsatsral, J., Matsuda, K., Sugihara, T., Shimizu, T., Koyanagi, M., Terakita, A., and Hibi, M.* (2023) Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells. eLife 12, e83974. doi: 10.7554/eLife.83974.
    121. Hagio, H., Koyama, W., Hosaka, S., Song, A.D., Narantsatsral, J., Matsuda, K., Shimizu, T., Hososhima, S., Tsunoda, S.P., Kandori, H., and Hibi, M.* (2023) Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases. eLife 12, e83975. doi: 10.7554/eLife.83975.
    122. Auer, F., Nardone, K., Matsuda, K, Hibi, M., and Schoppik, D.* (2023) Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (Danio rerio). bioRxiv. Sep 14:2023.09.12.557469. doi: 10.1101/2023.09.12.557469.
    123. Miyadai, M., Takeda, H., Shiraishi, A., Kimura, T., Watakabe, I., Kobayashi, H., Nagao, Y., Naruse, K., Higashijima S.I., Shimizu, T., Kelsh, R.N., Hibi, M., and Hashimoto, M.* (2023) A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish. Development 150, dev202114. doi: 10.1242/dev.202114.
    124. Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., and Hibi, M.* (2024) Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish. Development 151: doi: 10.1242/dev.202546.

 

Review Articles

  1. Hirano, T., Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Hibi, M., Natsuka, S., and Kishimoto, T. Structure and expression of interleukin-6 receptor. (1989) In: The Biology of Interferon System 1988, edt. by Y. Kawade and S. Kobayashi,. p.143-147.
  2. Hirano, T., Taga, T., Yamasaki, K., Matsuda, T., Suematsu, S., Tang, B., Hirata, Y., Yawata, H., Hibi,, Natsuka, S., Akira, S., Yoshizaki, K., Kawano, K., Yamamura, K., and Kishimoto, T. (1989) Interleukin-6 and its receptor. In: Receptor Progress in Cytokine Research. p.265-285.
  3. Kishimoto, T., Taga, T., Matsuda, T., Hibi, M., Suematsu, S., Tang, B., Yawata, H., Hirata, Y., Yamasaki, K., and Hirano, T. (1989) Interleukin-6 and its receptor in immune regulation. In: Progress in Immunology, edt. by F. Melchers et al., Springer-Verlag Berlin Heidel berg, Vol. 7, 633-640.
  4. Hirano, T. Taga, T., Matsuda, T., Hibi, M., Suematsu, S., Tang, B., Murakami, M., and Kishimoto, T. (1990) Interleukin 6 and its receptor in the immune response and hematopoiesis. Intl. J. Cell Cloning 8, 155-166.
  5. Kishimoto, T., Hirano, T., Taga, T., Matsuda, T., Suematsu, S., Hibi, M., Yamasaki, K., Yasukawa, K., and Hirata, Y. (1990) The immunobiology of interleukin-6 (IL-6) and its receptor. In: Advances in Host Defense Mechanisms Vol. 7 “Molecular Aspects of Immune Response and Infectious Deiseases: edt. by H. Kiyono, E. Jirillo, and C. Desimone, Raven Press, Ltd., New York. p.19-22.
  6. Suematsu, S., Hibi, M., Sugita, T., Saito, M., Murakami, M., Matsusaka, T., Matsuda, T., Hirano, T., Taga, T., and Kishimoto, T. (1990) Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma, plasmacytoma. Current Topics in Microbiology and Immunology. 166, 13-22.
  7. Taga, T., Hibi, M. Murakami, M., Saito, M., Yawata, H., Narazaki, M., Hirata, Y., Sugita, T., Yasukawa, K., Hirano, T., and Kishimoto, T. (1992) Interleukin-6 receptor and signals. Chemical Immunology 51, 181-204.
  8. Kishimoto, T., Hibi, M., Murakami, M., Narazaki, M., Saito, M., and Taga, T. (1992) The molecular biology of interleuin 6 and its receptor. Ciba Foundation Symposium 167, 5-16,.
  9. Hibi, M., Nakajima, K., and Hirano, T. (1996) IL-6 cytokine family and signal transduction: a model of the cytokine system. J. Mol. Med. 74: 1-12.
  10. Hirano, T., Nakajima, K, and Hibi, M. (1997) Signaling mechanisms through gp130: a model of the cytokine system. Cytokine & Growth Factor Reviews, 8, 241-252.
  11. Hibi, M. and Hirano, T. (1998) Signal transduction through cytokine receptors. Intern. Rev. Immunol. 17, 75-102.
  12. Fukada, T., Yoshida, Y., Nishida, K., Ohtani, T., Shirogane, T., Hibi, M., and Hirano, T. (1999) Signaling through gp130: toward a general senario of cytokine action. Growth Factors 17, 81-91.
  13. Hibi, M. and Hirano, T. (2000) Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. Leukemia and Lymphoma, 37, 299-307.
  14. Ohtani, T., Ishihara, K., Atsumi, T., Yoshida, Y., Nishida, K., Narimatsu, M., Shirogane, T., Hibi, M., and Hirano, T. (2000) gp130-mediated signalings as therapeutic targets. Emerging Therapeutic Targets, 4, 459-479.
  15. Hirano, T., Ishihara, K., and Hibi, M. (2000) Roles of STAT3 in mediating the cell growth, differentiation, and survivial signals related through the IL-6 family of cytokine receptors. Oncogene, 19, 2548-2556.
  16. Hibi, M., Hirano, T., and Dawid, I.B. (2002) Organizer formation and function. Results Probl Cell Differ. 40, 48-71.
  17. Shimizu, T. and Hibi, M.* (2009) Formation and patterning of the forebrain and olfactory system by zinc-finger genes Fezf1 and Fezf2. Dev. Growth Differ. 51, 221-231.
  18. Hibi, M.* and Shimizu, T. (2012) Development of the cerebellum and cerebellar neural circuits. Dev. Neurobiol. 72, 282-301.
  19. Hashimoto, M.* and Hibi, M.* (2012) Development and evolution of cerebellar neural circuits. Dev. Growth Differ. 54, 373-389.
  20. Hibi, M.* and Shimizu, T. (2014) Deciphering Cerebellar Neural Circuitry Involved in Higher Order Functions Using the Zebrafish Model. In: Kondoh, H. and Kuroiwa, A. (Eds.), New Principles in Developmental Processes. Springer, pp. 161-184.
  21. Hibi, M.*, Matsuda, K., Takeuchi, M., Shimizu, T., and Murakami, Y. (2017) Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum. Dev. Growth Differ. 59, 228-243.
  22. Hibi, M.*, Takeuchi, M., Hashimoto, H., and Shimizu, T. (2018) Axis Formation and Its Evolution in Ray Finned Fish. In: Kobayashi, K., Kitano, T., Iwao, Y., and Kondo, M. (Eds.), Reproductive Developmental Strategies. Springer, pp. 709-742.
  23. Hibi, M.* and Shimizu, T. (2022) From Cerebellar Genes to Behaviors in Zebrafish. In: Sillitoe, R.V. (Eds.), Measuring Cerebellar Function. Neuromethods, vol 177. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2026-7_2.
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