Professor Martin Oudega, Ph.D., Professor of Physical Therapy and Human Movement Sciences & Neuroscience, Northwestern University, Chicago, USA
This is a summary of the curriculum vitae (CV) of Professor Martin Oudega, Ph.D., Professor of Physical Therapy and Human Movement Sciences & Neuroscience, Northwestern University, Chicago, USA.
Professor Oudega is originally from the Netherlands and a distinguished researcher in the field of spinal cord injury repair. He currently holds multiple positions, bridging fundamental research and medical applications. He holds two professorships, in Neuroscience and in Physical Therapy and Human Movement Sciences at Northwestern University in Chicago. In the same city, he is also a Research Scientist at the Shirley Ryan AbilityLab and a Research Health Scientist at the Edward J. Hines Veterans Affairs Medical Hospital. The Shirley Ryan AbilityLab is a not-for-profit comprehensive rehabilitation center with 242 private patient rooms that integrates extensive research into its patient care, attracting patients from all over the world. They advertise: “We treat more patients for stroke, spinal cord injury and brain injury than any other rehabilitation hospital.” In this center, Professor Oudega’s wife, Dr. Monica Perez, leads the Neuromodulation & Motor Control Lab, while she is also a Professor in Physical Medicine and Rehabilitation at Northwestern University. The Edward Hines Jr. VA Hospital is a comprehensive medical facility dedicated to serving U.S. military veterans, and also has a large research facility.
Professor Oudega has an impressive list of >116 publications that generated 10647 citations and an h-index of 54 (Google Scholar).
Although his research overlaps with that of Fujita Health University, I know him because he is my relative. I am very happy and honored that he will give us a presentation!
Below he describes his work in his own words, followed by his CV:
Personal Statement
(by Professor Oudega; originally written for a different purpose and shortened and highlighted for this blog by Hans Dijkstra)
Current work
I am a Professor of Physical Therapy and Human Movement Sciences and of Neuroscience (Northwestern University), as well as a Research Health Scientist (Veteran Administration) and Research Scientist (Shirley Ryan AbilityLab). My lab is focused on developing clinically translatable strategies to repair anatomical damage and recover function after injury to the spinal cord or peripheral nerve. In my studies, I employ different animal models of injury to mimic the causes and consequences of nervous tissue injury in humans. I have a broad background in neurobiology, with emphasis on nervous tissue injury. I had extensive training and I am proficient in key areas in spinal cord and peripheral nerve injury and repair, particularly in spinal cord contusive injury or complete transection, peripheral nerve crush and transection, transplantation, behavioral testing, histological processing of nervous tissue, and qualitative and quantitative evaluation of anatomical repair and functional recovery.
Contributions to Science
My early work focused on the idea that regenerating axons fail to grow from a peripheral nerve transplant environment into the spinal cord nervous tissue due to a lack of supportive growth-promoting molecules. These publications showed that flooding the nervous tissue with neurotrophins (NGF, BDFN, NT3; alone or in combination), for which we employed custom-made infusion devices connected to an osmotic mini-pump, elicited regeneration of ascending sensory axons from a peripheral nerve graft into the rostral spinal cord. This approach has been repeated by different labs and in different models. I served as the primary investigator or co-investigator in a number of these studies (references Oudega and Hagg 1996; Oudega and Hagg 1999; Bamber et al. 2000; Blits et al. 2003). Other labs have designed and conducted approaches based on this idea.
Collectively, these studies demonstrate that increasing neurotrophic factor levels away from a transplant-spinal cord interface can attract regenerating axons into the spinal nervous tissue. The relevance of this work lies in the fact that growth of regenerating axons back into the nervous tissue of the injured spinal cord is the first crucial step towards reconnecting axons with their original or a new target neuron and recover of controlled motor behaviors.
My later work focused on the use of biomaterials alone and in combination with cells for the injured spinal cord and peripheral nerve. Schwann cells and bone marrow-derived mesenchymal stem/stromal cells (MSC) were used in these studies. The versatility of artificial biomaterials allows for fabrication of uni- or multichannel scaffolds that can serve to contain repair-supporting cells and/or to guide regenerating axons across an injury towards the opposite spinal cord nervous tissue. I have explored and successfully employed different types of scaffolds made from FDA-approved PLA for use in open injuries such as partial or complete transections. I have also employed artificial biomaterials for use in closed (contusion) injuries, which are clinically most relevant. I have used ESHU a reverse thermal (gels after injection into the spinal cord) as a medium to transplant and promote survival of repair-supporting MSC. (references Haggerty et al. 2019; Li et al. 2020; Puhl et al. 2020; Haggerty et al. 2022)
SCs and MSCs have been known for their remarkable ability to support repair of various types of tissue presumably through various mechanism including the release of repair supporting molecules. My work has focused on the potential of SCs and MSCs to repair the contused spinal cord. Our first work in this area identified the potential, possible mechanism of action, as well as potential shortcomings of SCs. The later work focused on early death of transplanted MSCs as a main contributor to the overall limited repair effects elicited by MSCs grafts. The inflammatory response has received much attention in my recent work. (references Takami et al. 2002; Hill et al. 2007; Maldonado-Lasunción et al. 2021b; 2021a)
My work has for long involved neuroplasticity in the damaged spinal cord and CNS. Whether through studying how to circumvent obstructive barriers such as the glial scar or how to enhance innate growth abilities of damaged neurons. Neurostimulation paradigms have been part of these studies. (references Hurtado et al. 2008; Oudega et al. 2012; Jo et al. 2021; 2023)
Curriculum Vitae (CV)
Education
1990 Ph.D., Medical Biology, University of Leiden, Leiden, the Netherlands; Title of dissertation: Development of the rat spinal cord. Histochemistry of some functional and structural parameters.
1985 MSC., Medical Biology, Free University, Amsterdam, the Netherlands
Current Academic Positions
2020-present Professor, Department of Neuroscience, Northwestern University, Chicago, USA
2020-present Professor, Department of Physical Therapy & Human Movement Sciences, Northwestern University, Chicago, USA
2020-present Research Scientist, Shirley Ryan AbilityLab, Chicago, USA
2019-present Research Health Scientist, Edward J. Hines Veterans Affairs Medical Hospital, Chicago, USA
Previous Academic Positions
2019 Research Professor, Department of Neurological Surgery, University of Miami School of Medicine, Miami, USA
2016-2019 Research Health Scientist, Bruce W. Carter Veterans Affairs Medical Center, Miami, USA
2015-2019 Research Associate Professor, Department of Neurological Surgery, University of Miami School of Medicine, Miami, USA
2010-2015 Training Faculty, Center for Pain Research, University of Pittsburgh, Pittsburgh, USA
2009-2015 Training Faculty, Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, USA
2008-2015 Assistant Professor, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, USA
2008-2015 Assistant Professor (secondary appointment), Department of Bioengineering, University of Pittsburgh, Pittsburgh, USA
2008-2015 Training Faculty, Center for Neuroscience, University of Pittsburgh, Pittsburgh, USA
2005-2008 Assistant Professor, Department of Neurology, Johns
Hopkins University, Baltimore, USA
2003-2004 Visiting Professor, Department of Medical Physiology, University of Copenhagen, Denmark
2001-2005 Assistant Professor, Department of Neurological Surgery,
University of Miami School of Medicine, Miami, USA
2000-2001 Research Assistant, Department of Neurological Surgery,
University of Miami School of Medicine, Miami, USA
1999-2000 Instructor, Department of Neurological Surgery,
University of Miami School of Medicine, Miami, USA
Journal Editorial Appointments
2015-present Editorial Board, Frontiers in Neuroscience
2014-present Executive Editor, Biochemistry and Biophysics Reports
2013-present Editorial Board, Journal of Spine
2013-present Editorial Board, BioMed Research International
2011-present Editorial Board, Neural Regeneration Research
2011-present Associate Editor, Restorative Neurology and Neuroscience
2013-2017 Editorial Board, Neural Plasticity
PUBLICATIONS
Peer-reviewed journal articles:
(116 in total)
(1) Gaikwad S, Chen Y, Vaughan T, Carp J, Oudega M, Wolpaw J, Perez MA. Electrophysiological evidence of spike-timing dependent plasticity in the awake adult rat. J Neurophys. Submitted.
(2) Chen B, Gaikwad S, Powell RH, Jo HJ, Kessler A, Chen D, Heckman CJ, Jones L, Guest J, Wolpaw J, Oudega M, Blight AR, Perez MA. Combinatorial approaches targeting synaptic transmission accelerate recovery in humans with spinal cord injury. Brain. 2024. Submitted.
(3) Wolpaw JR, Thompson AK, Perez MA, Norman SL, Oudega M, Winstein C. Neurorehabilitation in the 21st Century: New Science, New Strategy, New Expectations. Brain. 2024. Submitted.
(4) Sangari S, Chen B, Hobbs S, Olson A, Anschel A, Kim K, Chen D, Kessler A, Heinemann AW, Oudega M, Kwon BK, Kirshblum S, Guest JD, Perez MA. Reply to “Letter on Spasticity Predicts Motor Recovery in Motor Complete Spinal Cord Injury.” Ann Neurol. 2024; 95(5), 1011-1012.
(5) Lee MK, Lee H, Kang MH, Hwang C, Kim HE, Oudega M, Jang TS, Jung HD. Bioinspired nanotopography for combinatory osseointegration and antibacterial therapy. ACS Appl Mater Interfaces. 2024; 16(24), 30967-30979.
(6) Stratton S, Wang S, Hashemi S, Pressman Y, Nanchanatt J, Oudega M, Arinzeh T. A scaffold containing zinc oxide for Schwann cell-mediated axon growth. J Neural Eng. 2023; 20(6), 066009.
(7) Sangari S, Chen B, Grover F, Salsabili H, Sheth M, Gohil K, Hobbs S, Olson A, Ki K, Chen D, Kessler A, Oudega M, Kwon B, Kirshblum S, Guest JD, Perez MA. Spasticity predicts motor recovery in humans with subacute motor complete spinal cord injury. Ann Neurol. 2024; 95, 71-86.
(8) Puhl DL, Funnell JL, Fink TD, Swaminathan A, Oudega M, Zha H, Gilbert RJ. Electrospun fiber-mediated delivery of neurotrophin-3 mRNA for neural tissue engineering applications. Acta Biomaterialia. 2023; 155, 370-385.
(9) Jo HJ, Kizziar E, Sangari S, Chen D, Kessler A, Kim K, Anschell A, Heineman A, Mensh BD, Awadalla S, Lieber RL, Oudega M, Perez MA. Multisite Hebbian plasticity restores function in humans with spinal cord injury. Ann Neurol. 2023; 93(6), 1198-1213.
(10) Haggerty AE, Maldonado-Lasunción I, Nitobe Y, Yamane K, Marlow MM, You H, Zhang C, Cho B, Li X, Reddy S, Mao H-Q, Oudega M. The effects of the combination of mesenchymal stromal cells and nanofiber-hydrogel composite on repair of the contused spinal cord. Cells. 2022; 11, 1137.
(11) Torres-Espín A, Almeida CA, Chou A, Huie JR, Chiu M, Vavrek R, Sacramento J, Orr MB, Gensel JC, Grethe JS, Martone ME, Fouad K, Ferguson AR; STREET-FAIR Workshop Participants. Promoting FAIR Data Through Community-driven Agile Design: the Open Data Commons for Spinal Cord Injury (odc-sci.org). Neuroinformatics. 2021; 20(1), 203-219.
(12) Jo HJ, Richardson MSA, Oudega M, Perez MA. Paired corticospinal-motoneuronal stimulation and exercise after spinal cord injury. J Spinal Cord Med. 2021; 4(Supp 1), S23-S27.
(13) Sangari S, Kirshblum S, Guest JD, Oudega M, Perez MA. Distinct patterns of spasticity and corticospinal connectivity following complete spinal cord injury. J Physiol. 2021; 599(19), 4441-4454.
(14) Maldonado-Lasunción I, Haggerty AE, Okuda A, Mihara T, de la Oliva N, Verhaagen J, Oudega M. The effect of inflammatory priming on the therapeutic potential of mesenchymal stromal cells for spinal cord repair. Cells. 2021a; 10(6), 1316.
(15) Sandhu MS, Perez MA, Oudega M, Mitchell GS, Rymer WZ. Efficacy and time course of acute intermittent hypoxia effects in the upper extremities of people with cervical spinal cord injury. Exp Neurol. 2021; 342, 113722.
(16) Maldonado-Lasunción I, O’Neill N, Umland O, Verhaagen J, Oudega M. Macrophage-derived inflammation induces a transcriptome makeover in mesenchymal stromal cells enhancing their potential for tissue repair. Int J Mol Sci. 2021b; 22(2), E781.
(17) Christiansen L, Chen B, Lei Y, Urbin MA, Richardson MS, Oudega M, Sandhu M, Rymer MZ, Trumbower RD, Mitchell GS, Perez MA. Acute Intermittent Hypoxia Boosts Spinal Plasticity in Humans with Tetraplegia. Exp Neurol. 2020; 335, 113483.
(18) Puhl DL, Funnell JL, D’Amato AR, Bao J, Zagorevski DV, Pressman Y, Morone D, Haggerty AE, Oudega M, Gilbert RJ. Aligned fingolimod-releasing electrospun fibers increase dorsal root ganglia neurite extension and decrease Schwann cell expression of promyelinating factors. Front Bioeng Biotechnol. 2020; 8, 937.
(19) Jo HJ, Richardson MSA, Oudega M, Perez MA. The potential of corticospinal-motoneuronal plasticity for recovery after spinal cord injury. Curr Phys Med Rehabil Rep. 2020; 8, 293-298.
(20) Li X, Zhang C, Haggerty AE, Yan J, Lan M, Seu M, Yang M, Marlow MM, Maldonado-Lasunción I, Cho B, Zhou Z, Chen L, Martin R, Nitobe Y, Yamane K, You H, Reddy S, Quan D-P, Oudega M, Mao H-Q. The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord. Biomaterials. 2020; 245, 119978.
(21) Haggerty AE, Bening MR, Pherribo G, Dauer EA, Oudega M. Laminin polymer treatment accelerates repair of the crushed peripheral nerve in adult rats. Acta Biomaterialia. 2019; 86, 185-193.
(22) Oudega M, Duan H, Shang J, Hao P, Haggerty AE, Wang Z, Sun J, Liebl DJ, Shi Y, Cheng L, Yang Z, Sun YE, Li X, Lemmon VP. Validation study of neurotrophin-3 releasing chitosan facilitation of neural tissue generation in the severely injured adult rat spinal cord. Exp Neurol. 2019; 312, 51-62.
(23) Maldonado-Lasunción I, Verhaagen J, Oudega M. Mesenchymal stem cell-macrophage choreography supporting spinal cord repair. Neurotherapeutics. 2018; 15(3), 578-587.
(24) Haggerty AE, Maldonado-Lasuncion I, Oudega M. Biomaterials for revascularization and immunomodulation after spinal cord injury. Biomed Mater. 2018; 13(4), 044105.
(25) Haggerty AE, Al-Ali H, Oudega M. Soluble laminin polymers enhance axon growth of primary neurons in vitro. J Biomed Mater Res A. 2018; 106(9), 2372-2381.
(26) Haggerty AE, Marlow MM, Oudega M. Extracellular matrix components as therapeutics for spinal cord injury. Neurosci Lett. 2017; 652, 50-55.
(27) Thiruumala P, Zhou J, Krishnan R, Manem N, Umredkar S, Hamilton DK, Balzer JR, Oudega M. Diagnostic accuracy of evoked potentials for functional impairment after contusive spinal cord injury in adult rats. J Clin Neurosci. 2016; 25, 122-126.
(28) Rauck BM, Novosat TL, Oudega M, Wang Y. Biocompatibility of a coacervate-based controlled release system for protein delivery to the injured spinal cord. Acta Biomaterialia. 2015; 11, 204-211.
(29) Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. Large animal and primate models of spinal cord injury for the testing of novel therapies. Exp Neurol. 2015; 269, 154-168.
(30) Ritfeld GJ, Patel A, Chou A, Novosat TL, Castillo DG, Roos RAC, Oudega M. The role of brain-derived neurotrophic factor in bone marrow stromal cell-mediated spinal cord repair. Cell Transplantation. 2015; 24(11), 2209-2220.
(31) Tapanes-Castillo A, Shabazz F, M’boge M, Vajn K, Oudega M, Plunkett AJ. Characterization of a novel primary culture system of adult zebrafish brainstem cells. J Neurosci Meth. 2014; 223, 11-19.
(32) Ritfeld GJ, Rauck B, Novosat TL, Park D, Patel P, Roos RAC, Wang Y, Oudega M. The effect of a urethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair. Biomaterials. 2014; 35(6), 1924-1931.
(33) Vajn K, Suler D, Plunkett JA, Oudega M. Temporal profile of endogenous anatomical repair and functional recovery following spinal cord injury in adult zebrafish. PLOS ONE. 2014; 9(8), e105857.
(34) Ritfeld GJ, Oudega M. Bone marrow stromal cell therapy for spinal cord repair. Phys Med Rehab Int. 2014; 1(3), 6.
(35) Ritfeld GJ, Oudega M. Bone marrow-derived mesenchymal stem cell transplant survival in the injured rodent spinal cord. J Bone Marrow Res. 2014; 2(2), 146.
(36) Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL; MIASCI Consortium: Abeyruwan SW, Beattie MS, Bethea JR, Bradke F, Bresnahan JC, Bunge MB, Callahan A, David S, Dunlop SA, Fawcett JW, Fehlings MG, Fischer I, Forscher P, Giger J, Goshima Y, Grimpe B, Hagg T, Hall ED, Harrison BJ, Harvey AR, Hirata T, Hoke A, Hulsebosch CE, Hurtado A, Jain A, Kadoya K, Kamiguchi H, Kengaku M, Kocsis JD, Kwon BK, Lee J, Liebl DJ, Liu SJ, Lowery LA, Hill C, Mandrekar-Colucci S, Martin JH, Mason CA, McTigue DM, Mokarram N, Moon LD, Müller HW, Nakamura T, Namba T, Nishibe M, Oinuma I, Oudega M, Pleasure DE, Raisman G, Rasband MN, Reier PJ, Santiago-Medina M, Schwab JM, Schwab ME, Shinmyo Y, Silver J, Smith GM, Sofroniew MV, Strittmatter SM, Tuszynski MH, Twiss JL, Visser U, Watkins TA, Wu W, Yoon SO, Yuzaki M, Zheng B, Zhou F, Zou Y. Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J Neurotrauma. 2014; 31(15), 1354-1361.
(37) Mountney A, Zahner MR, Sturgill ER, Riley CJ, Aston JW, Oudega M, Schramm LP, Hurtado A, Schnaar RL. Sialidase, chondroitinase ABC and combination therapy after spinal cord contusion injury. J Neurotrauma. 2013; 30(3), 181-190.
(38) Vajn K, Plunkett JA, Tapanes-Castillo A, Oudega M. Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation. Neurosci Bull. 2013; 29(4), 402-410.
(39) Haggerty A, Oudega M. Biomaterials for spinal cord repair. Neurosci Bull. 2013; 29(4), 445-459.
(40) Kwon BK, Soril LJ, Bacon M, Beattie MS, Blesch A, Bresnahan JC, Bunge MB, Dunlop S, Fehlings MG, Ferguson AR, Hill C, Karimi-Abdolrezaee S, Lu P, McDonald JW, Müller HW, Oudega M, Rosenzweig ES, Reier PJ, Silver J, Sykova E, Xu XM, Guest J, Tetzlaff W. Demonstrating efficacy in preclinical studies of cellular therapies for spinal cord injury—How much is enough? J Neurotrauma. 2013; 30(3), 44-60.
(41) Oudega M. Inflammatory response after spinal cord injury. Exp Neurol. 2013; 250, 151-155.
(42) Bunday KL, Oudega M, Perez MA. Aberrant crossed corticospinal facilitation in muscles distant from a spinal cord injury. PLoS ONE. 2013; 8(10), e76747.
(43) Ritfeld GJ, Nandoe Tewarie RDS, Vajn K, Rahiem ST, Hurtado A, Wendell DF, Roos RAC, Oudega M. Bone marrow stromal cell-mediated tissue sparing enhances functional repair after spinal cord contusion in adult rats. Cell Transplantation. 2012; 21(6), 1-15.
(44) Oudega M, Perez MA. Corticospinal reorganization after spinal cord injury. J Physiol. 2012; 590(Pt16), 3647-3663.
(45) Oudega M. Molecular and cellular mechanisms underlying the role of blood vessels in spinal cord injury and repair. Cell Tissue Res. 2012; 349(1), 269-288.
(46) Oudega M, Chao OY, Avison DL, Bronson RT, Buchser WJ, Hurtado A, Grimpe B. Systemic administration of a deoxyribozyme to xylosyltransferase-1 mRNA promotes recovery after a spinal cord contusion injury. Exp Neurol. 2012; 237(1), 170-179.
(47) Oudega M, Bradbury EJ, Ramer MS. Combination Therapies. Handb Clin Neurol. 2012; 109, 617-636.
(48) Kwon BK, Okon EB, Tsai E, Beattie MS, Brenahan JC, Magnuson DK, Reier PJ, McTigue DM, Popovich PG, Blight AR, Oudega M, Guest JD, Weaver LC, Fehlings MG, Tetzlaff W. A grading system to evaluate objectively the strength of pre-clinical data of acute neuroprotective therapies for clinical translation in spinal cord injury. J Neurotrauma. 2011; 28(8), 1525-1543.
(49) You H, Wei L, Liu Y, Oudega M, Jiao SS, Feng SN, Chen Y, Chen JM, Li BC. Olfactory ensheathing cells enhance Schwann cell-mediated anatomical and functional repair after sciatic nerve injury in adult rats. Exp Neurol. 2011; 229(1), 158-167.
(50) Nandoe Tewarie RDS, Bossers K, Ritfeld GJ, Blits B, Grotenhuis JA, Verhaagen J, Oudega M. Early passage bone marrow stromal cells express genes involved in nervous system development supporting their relevance for neural repair. Restor Neurol Neurosci. 2011; 29(3), 187-201.
(51) Ritfeld GJ, Roos RAC, Oudega M. Stem cells for CNS repair and rehabilitation. PM&R. 2011; 3(6), 117-122.
(52) Hurtado A, Cregg JM, Wang HB, Wendell DF, Oudega M, Gilbert RJ, McDonald JW. Robust CNS regeneration after complete spinal cord transection using aligned poly-L-lactic microfibers. Biomaterials. 2011; 32(26), 6068-6079.
(53) Ritfeld GJ, Nandoe Tewarie RDS, Rahiem ST, Hurtado A, Roos RA, Grotenhuis JA, Oudega M. Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. Neuroreport. 2010; 21(3), 221-226.
(54) Nandoe Tewarie RDS, Yu J, Seidel J, Rahiem ST, Hurtado A, Tsui BMW, Grotenhuis JA, Pomper MG, Oudega M. Positron emission tomography for serial imaging of the contused adult rat spinal cord. Mol Imaging. 2010; 9(2), 108-116.
(55) Oudega M. Spinal cord injury and repair: role of blood vessel loss and endogenous angiogenesis. Advances in Wound Care. 2010; 1, 335-340.
(56) Mountney A, Zahner MR, Lorenzini I, Oudega M, Schramm LP, Schnaar RL. Sialidase enhances recovery from spinal cord contusion injury. Proc Natl Acad Sci USA. 2010; 107(25), 11561-11566.
(57) Nandoe Tewarie RDS, Hurtado A, Bartels RHMA, Grotenhuis JA, Oudega M. A clinical perspective of spinal cord injury. NeuroRehabilitation. 2010; 27, 129-139.
(58) Wang HB, Mullins ME, Cregg JM, Hurtado A, Oudega M, Trombley MT, Gilbert RJ. Creation of highly aligned electrospun poly-L-lactic acid fibers for nerve regeneration applications. J Neural Eng. 2009; 6(1): 016001.
(59) Cai PG, Sun GQ, Cai P, Oudega M, Xiao R, Wang X, Li W, Shu Y, Cai C, Yang H, Shan X, Luo W. Survival of transplanted neurotrophin-3 expressing human neural stem cells and motor function in a rat model of spinal cord injury. Neural Regen Res. 2009; 4(7), 485-491.
(60) Nandoe Tewarie DS, Hurtado A, Bartels RHMA, Grotenhuis A, Oudega M. Stem-cell-based therapies for spinal cord injury. J Spinal Cord Med. 2009; 32(2): 105-114.
(61) Ylera B, Ertürk A, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F. Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Curr Biol. 2009; 19, 930-936.
(62) Brambilla R, Hurtado A, Persaud T, Esham K, Pearse DD, Oudega M, Bethea JR. Transgenic inhibition of astroglial NF-κB leads to increased axonal sparing and sprouting following spinal cord injury. J Neurochem. 2009; 110, 765-778.
(63) Nandoe Tewarie RDS, Hurtado A, Ritfeld GJ, Rahiem ST, Wendell DF, Barroso MMS, Grotenhuis JA, Oudega M. Bone marrow stromal cells elicit tissue sparing after acute but not delayed transplantation into the contused adult rat thoracic spinal cord. J Neurotrauma. 2009; 26(12), 2313-2322.
(64) Hurtado A, Podinin H, Oudega M, Grimpe B. Deoxyribozyme-mediated knockdown of xylosyltransferase-1 mRNA promotes axon growth in the adult rat spinal cord. Brain. 2008; 131(Pt 10), 2596-2605.
(65) Belegu V, Oudega M, Gary DS, McDonald JW. Restoring function after spinal cord injury: promoting spontaneous regeneration with stem cells and activity-based therapies. Neurosurg Clin N Am. 2007; 18(1), 143-168.
(66) Nielsen JB, Perez MA, Oudega M, Enriquez-Denton M, Aimonetti J-M. Evaluation of transcranial magnetic stimulation for investigating transmission in descending motor tracts in the rat. Eur J Neurosci. 2007; 25(3), 805-814.
(67) Golden KL, Pearse DD, Blits B, Garg MS, Oudega M, Wood PM, Bunge MB. Transduced Schwann cells promote axon growth and myelination after spinal cord injury. Exp Neurol. 2007; 207(2), 203-217.
(68) Oudega M. Schwann cells and olfactory ensheathing cell implantation for repair of the contused spinal cord. Acta Physiol (Oxf). 2007; 189(2), 181-189.
(69) Hill CE, Hurtado A, Blits B, Bahr B, Wood PM, Bunge MB, Oudega M. Early necrosis and apoptosis of Schwann cells transplanted into the moderately contused adult rat spinal cord. Eur J Neurosci. 2007; 26, 1422-1445.
(70) Hurtado A, Moon LDF, Maquet V, Blits B, Jérôme R, Oudega M. Poly (D,L-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord. Biomaterials. 2006; 27(3), 430-442.
(71) Cai PQ, Tang X, Lin YQ, Oudega M, Blits B, Sun GY, Xu L, Yang YK, Zhou TH. The experimental study of genetic engineering human neural stem cells mediated by lentivirus to express multigene. Chin J Traumatol. 2006; 9(1), 43-49.
(72) Tang X, Cai PQ, Lin YQ, Oudega M, Blits B, Xu L, Yang YK, Zhou TH. Genetic engineering neural stem cells modified by lentivirus for repair of spinal cord injury in rats. Chin Med Sci J. 2006; 21(2), 120-124.
(73) Oudega M, Xu XM. Schwann cell transplantation for repair of the adult spinal cord. J Neurotrauma. 2006; 23(3-4), 453-467.
(74) Hagg T, Oudega M. Degenerative and spontaneous regenerative processes following spinal cord injury. J Neurotrauma. 2006; 23(3-4), 264-280.
(75) Oudega M. Introduction: Experimental strategies to repair the injured spinal cord. J Neurotrauma. 2006; 23(3-4), vii-viii.
(76) Nandoe Tewarie RDS, Hurtado A, Levi ADO, Grotenhuis A, Oudega M. Bone marrow stromal cell for repair of the spinal cord: towards clinical application. Cell Transpl. 2006; 15, 563-577.
(77) Cai PQ, Tang X, Lin Y, Oudega M, Xu L, Blits B, Yang Y. Lentivirus-mediated neurotrophic factor-3 in the injured adult rat spinal cord improves hind limb functional recovery. Chin J Trauma. 2005; 21(7), 485-490.
(78) Oudega M, Moon LDF, Leme RJ. Schwann cells for spinal cord repair. Braz J Med Biol Res. 2005; 38(6), 825-835.
(79) Cai PQ, Tang X, Lin Y, Oudega M, Blits B, Xu L, Yang Y. The experimental study of genetic engineering human stem cells producing neurotrophic factor-3 mediated by lentivirus. Chin J Surg. 2005; 43(16), 1091-1093.
(80) Pearse DD, Marcillo AE, Oudega M, Lynch MP, Wood PM, Bunge MB. Transplantation of Schwann cells and olfactory ensheathing glia after spinal cord injury: Does pretreatment with methylprednisolone and interleukin-10 enhance recovery? J Neurotrauma. 2004; 21(9), 1223-1239.
(81) Patist CM, Borgerhoff Mulder M, Gautier SE, Maquet V, Jérôme R, Oudega M. Freeze-dried poly (D,L-lactic acid) macroporous guidance scaffolds impregnated with brain-derived neurotrophic factor in the transected adult rat thoracic spinal cord. Biomaterials. 2004; 25, 1569-1582.
(82) Meijs MFL, Timmers L, Pearse DD, Tresco PA, Bates ML, Joosten EAJ, Bunge MB, Oudega M. Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord. J Neurotrauma. 2004; 21(10), 1415-1430.
(83) Blits B, Oudega M, Boer GJ, Bunge MB, Verhaagen J. Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind limb function. Neurosci. 2003; 118(1), 271-281.
(84) Plant GW, Christensen CL, Oudega M, Bunge MB. Delayed transplantation of olfactory ensheathing glia promotes regeneration/sparing of supraspinal axons in the moderately contused adult rat spinal cord. J Neurotrauma. 2003; 20(1), 1-16.
(85) Eaton MJ, Blits B, Ruitenberg MJ, Verhaagen J, Oudega M. Amelioration of chronic neuropathic pain by adenoviral-associated viral vector-mediated overexpression of BDNF in the rat spinal cord. Gene Therapy. 2002; 9(20), 1387-1395.
(86) Takami T, Oudega M, Wood PM, Kleitman N, Bunge MB. Methylprednisolone administration alone or combined with interleukin-10 reduces loss of gray matter in the contused adult rat thoracic spinal cord but does not improve functional outcome. J Neurotrauma. 2002; 19(5), 653-666.
(87) Takami T, Oudega M, Bates ML, Wood PM, Kleitman N, Bunge MB. Schwann cell but not olfactory ensheathing glia transplants improve hindlimb performance in the moderately contused adult rat thoracic spinal cord. J Neurosci. 2002; 22(15), 6670-6681.
(88) De Winter F, Oudega M, Lankhorst AJ, Hamers FP, Blits B, Ruitenberg MJ, Pasterkamp RJ, Gispen WH, Verhaagen J. Injury-induced class III semaphorin expression in the rat spinal cord. Exp Neurol. 2002; 175, 61-75.
(89) Sayer FT, Oudega M, Hagg T. Neurotrophins reduce degeneration of injured ascending sensory and corticospinal motor axons in adult rat spinal cord. Exp Neurol. 2002; 175, 282-296.
(90) Jones LL, Oudega M, Bunge MB, Tuszynski MH. Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. J Physiol. 2001; 533, 83-89.
(91) Pinzon A, Calancie B, Oudega M, Noga BR. Conduction of impulses by axons regenerated in a Schwann cell graft in the transected adult rat thoracic spinal cord. J Neurosci Res. 2001; 64, 533-541.
(92) Oudega M, Gautier SE, Chapon P, Fragoso M, Bates ML, Parel J-M, Bunge MB. Axonal regeneration into Schwann cell grafts within resorbable poly(α-hydroxyacid) guidance channels in the adult rat spinal cord. Biomaterials. 2001; 22(10), 1125-1136.
(93) Li X, Oudega M, Dancausse H, Levi ADO. The effect of methylprednisolone on caspase-3 activation after rat spinal cord transection. Rest Neurol Neurosci. 2001; 17(4), 203-209.
(94) Bamber NI, Li H, Lu X, Oudega M, Aebischer P, Xu XM. Neurotrophins BDNF and NT-3 promote axonal reentry into the distal host spinal cord through Schwann cell-seeded mini-channels. Eur J Neurosci. 2000; 13(2), 257-268.
(95) Oudega M, Rosano C, Sadi D, Wood PM, Schwab M, Hagg T. Neutralizing antibodies against neurite growth inhibitor NI-35 do not promote sensory axonal regeneration in the adult rat spinal cord. Neurosci. 2000; 100, 873-883.
(96) Cejas PJ, Martinez M, Karmally S, McKillop M, McKillop J, Plunkett JA, Oudega M, Eaton MJ. Lumbar transplants of neurons genetically modified to secrete brain-derived neurotrophic factor attenuate allodynia and hyperalgesia after sciatic nerve constriction. Pain. 2000; 86, 195-210.
(97) Oudega M, Vargas CG, Weber AB, Kleitman N, Bunge MB. Long-term effects of methylprednisolone following transection of adult rat spinal cord. Eur J Neurosci. 1999; 11, 2453-2464.
(98) Oudega M, Hagg T. Neurotrophins promote regeneration of sensory axons in the adult rat spinal cord. Brain Res. 1999; 818, 431-438.
(99) Oudega M, Gautier SE. Spinal cord repair strategies: Schwann cells, neurotrophic factors and biodegradable polymers. Biomed Rev. 1999; 10, 75-88.
(100) Gautier SE, Oudega M, Fragoso M, Chapon P, Plant GW, Bunge MB, Parel J-M. Poly (α-hydroxyacids) for application in the spinal cord: resorbability and biocompatibility with adult Schwann cells and spinal cord. J Biomed Mater Res. 1998; 42, 642-654.
(101) Oudega M, Touri F, Deenen MGM, Riederer BM, Marani E. Microtubule-associated protein la is involved in the early development of the rat spinal cord. Neurosci Lett. 1998; 246, 81-84.
(102) Oudega M, Xu XM, Guénard V, Kleitman N, Bunge MB. A combination of insulin-like growth factor-I and platelet-derived growth factor enhances myelination but diminishes axonal regeneration into Schwann cell grafts in the adult rat spinal cord. Glia. 1997; 19(3), 247-258.
(103) Gautier SE, Oudega M, Fragoso M, Plant GW, Bunge MB, Parel J-M. In vitro and in vivo biocompatibility of bioresorbable poly(α-hydroxyacids) with Schwann cells and adult rat spinal cord. Proc Topical Conf Biomaterials. 1997, 120-122.
(104) Oudega M, Voormolen JH, Usunoff KG, Marani E, Thomeer RTWM. Immunocytochemical localization of neurofilaments in the fibre systems of the developing rat spinal cord white matter. Eur J Morph. 1996; 140(2), 218-229.
(105) Oudega M, Hagg T. Nerve growth factor promotes regeneration of sensory axons into the adult rat spinal cord. Exp Neurol. 1996; 140(2), 218-229.
(106) Oudega M, Touri F, Deenen MGM, Riederer BM, Marani E. Immunocytochemical localization of microtubule-associated protein lb and 2 in the developing rat spinal cord. J Anat. 1995; 187, 723-737.
(107) Oudega M, Varon S, Hagg T. Regeneration of adult rat sensory axons into intraspinal nerve grafts: promoting effects of conditioning lesion and graft pre-degeneration. Exp Neurol. 1994; 129(2), 194-206.
(108) Oudega M, Varon S, Hagg T. Distribution of corticospinal motor neurons in the postnatal rat: quantitative evidence for massive collateral elimination and modest cell death. J Comp Neurol. 1994; 347(1), 115-126.
(109) Magal E, Louis J-C, Oudega M, Varon S. CNTF promotes the survival of neonatal rat corticospinal neurons in vitro. NeuroReport. 1993; 4(6), 779-782.
(110) Hagg T, Rende M, Magal E, Burnham P, Oudega M, Varon S. Potential regulation by trophic factors of low-affinity NGF receptors in spinal motor neurons. Brain Res Bull. 1993; 30(3-4), 347-352.
(111) Oudega M, Marani E, Thomeer RTWM. Transient expression of stage-specific embryonic antigen-1 (CD15) in the developing dorsal rat spinal cord. Histochemical J. 1992; 24(11), 869-877.
(112) Oudega M, Marani E. Expression of vimentin and glial fibrillary acidic protein in the developing rat spinal cord: An immunocytochemical study of the spinal cord glial system. J Anat. 1991; 179, 97-114.
(113) Oudega M, Marani E. Acetylcholinesterase in the developing rat spinal cord: An enzyme histochemical study. Eur J Morph. 1990; 28(2-4), 430-444.
(114) Dorp van R, Jalink K, Oudega M, Marani E, Ypey DL, Ravesloot JH. Morphological and functional properties of rat dorsal root ganglion cells cultured in a chemically defined medium. Eur J Morph. 1990; 28(2-4), 430-444.
(115) Coppes MH, Marani E, Thomeer RTWM, Oudega M, Groen GJ. Innervation of annulus fibrosis in low back pain. Lancet. 1990; 336(8708), 189-190 (erratum in 336(8710), 324).
(116) Ypey DL, Jalink K, Ravesloot JH, Struwe P, van Dorp R, Oudega M, Marani E. K+ conductance of mechanically dissociated rat sensory neurons in long-term cultures in a defined medium. Pflugers Arch-Eur J Physiol. 1989; 414(1), 123-130.
Books, Book chapters, and Monographs:
(9 in total)
- Dalton PD, O’Neill K, Pego, AP, Plant GW, Nisbet DR, Oudega M, Brook GA, Harvey AR. Tissue engineering of the nervous system. In: Tissue Engineering. Eds. Van Blitterswjik CA, de Boer J. Elsevier, Amsterdam. 2022; 585-628.
- Oudega M, Maldonado-Lasuncion I. Biomaterials and immunomodulation for spinal cord repair. In: Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome. Eds. Badylak S, Elisseeff J. Elsevier, Amsterdam. 2021; 119-138.
- Oudega M, Perez MA. Editors of Mechanisms of motor function recovery after spinal cord injury. Research Topic in Frontiers in Integrative Neuroscience. 2018.
- Dalton PD, Harvey AR, Oudega M, Plant GW. Tissue engineering of the nervous system. In: Tissue Engineering. Eds. Van Blitterswjik CA, de Boer J. Elsevier, Amsterdam. 2014; 583-622.
- Nandoe Tewarie RDS, Oudega M, Ritfeld GJ. Bone marrow stromal cells for repair of the injured spinal cord. In: New Advances in Stem Cell Transplantation. T. Demirer (Ed.) ISBN 978-953-51-0013-3, InTech. 2012.
- Dalton P, Harvey A, Oudega M, Plant GW. Tissue engineering of the nervous system. In: Tissue Engineering. Eds. Van Blitterswjik C, de Bruijn J, Cancedda P, Thomsen P, Hubbell J, Williams D, Lindhal A, Sohier J. Elsevier, Amsterdam. 2008; 611-647.
- Oudega M, Blits B, Verhaagen J, Boer GJ. Editors of Experimental strategies to repair the injured spinal cord. Special edition in J Neurotrauma. 2006; 23(3-4): 264-593.
- Oudega M, Sagen J. Spinal cord. In: Methods of Tissue Engineering. Eds. Atala, Lanza R. Academic Press, San Diego. 2001; 1143-1155.
- Hagg T, Oudega M. Neurotrophic factors and CNS regeneration. In: Spinal cord monitoring: basic principles, regeneration, pathophysiology and clinical aspects. Eds. Stålberg E, Sharma MS, Olsson Y. Springer Wien, New York. 1998; 129-156.
- Oudega M, Lakke EAJF, Marani E, Thomeer RTWM. Development of the rat spinal cord: immuno- and histochemical approaches. Advances in Anatomy, Embryology and Cell Biology. 1993; 129: 1-166.
- Oudega M. Development of the rat spinal cord. Histochemistry of some functional and structural parameters. Thesis. 1990; Leiden, the Netherlands.
