Prof. Ikue Mori, Ph.D., Senior Research Fellow of the Graduate School of Science in Nagoya University, and Professor Emeritus of Nagoya University

This is a summary of the curriculum vitae (CV) of Prof. Ikue Mori, Ph.D., Senior Research Fellow of the Graduate School of Science in Nagoya University, and Professor Emeritus of Nagoya University, Japan. In 2017, she established the Neuroscience Institute in the Graduate School of Science in Nagoya University, and has been acting as its first Director until very recently. She will give a presentation at Fujita Health University.

Professor Mori is famous in the field of neuroregulation of animal behavior.  She is especially known for studies on the behavioral responses of the nematode Caenorhabditis elegans (C. elegans; a “mini-worm” of about 1 mm), which despite its primitive state can learn how different temperatures are associated with food. C. elegans has only 302 neurons (!), making it a superior model for elucidating the neural networks involved in behavioral choices. In 2013, she became the first woman to receive the Tokizane Award, a prestigious neuroscience award in Japan. She has many papers in top journals, including in Nature, Science, and Cell.

She graduated from Ochanomizu University, Japan, in 1980 with a B.S. in Biology. While she was a M.S. student majoring in population genetics using Drosophila melanogaster (fruit fly) in Ochanomizu University, she studied theoretical biology and evolution at the University of Sussex, UK, under the supervision of Dr. Brian Charlesworth as a visiting student for one year, supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan.

From April to August in 1983, Dr. Ikue Mori was supervised by Dr. Kunitada Shimotohno to learn Molecular Biology at the National Cancer Research Center, Japan. In September 1983, she joined the Biology and Biomedical Science Program in Washington University, where she studied Genetics using C. elegans under the supervision of Dr. Robert Waterston.

After receiving her Ph.D., she was appointed as Assistant Professor at Kyushu University, Japan, where she started to work on thermotaxis in C. elegans, aiming to clarify molecular, neural, and circuit mechanisms underlying learning, memory and decision-making.

Since 1998, Dr. Ikue Mori established her lab in Nagoya University, Japan, where she was first appointed as Associate Professor, and became Full Professor in 2004. She established the Neuroscience Institute in the Graduate School of Science in Nagoya University in 2017, and has been acting as the first Director of this institute until recently.

Dr. Ikue Mori contributed to understand how a behavior is generated and executed using C. elegans as a model by the application of system-level and interdisciplinary approaches. Owing to her scientific achievements, she was honored by receiving the Saruhashi Award in 2006, the Inoue Prize for Science in 2006, the Tokizane Award in 2013, the Kihara Prize in 2013, the Chunichi Cultural Award in 2016, the Medal of Honor with Purple Ribbon in 2017, and the Toray Science and Technology Prize in 2023.

Dr. Ikue Mori is also acting as a Program Officer of the Interstellar Initiative, which is an international mentorship program for early career investigators organized by Japan Agency for Medical Research and Development (AMED).

CURRICULUM VITAE

EDUCATION

1980                       B.S., Biology, Ochanomizu University, Japan

1982-1983            Visiting graduate student at the University of Sussex, UK

                                Advisor: Professor Brian Charlesworth

1983                       M.S., Ochanomizu University, Japan

                                Topic: Population Genetics (fruit flies), Advisor: Professor Sadao Ishiwa

1983                       Visiting graduate student, National Cancer Center Research Institute, Japan

                                Advisor: Professor Kunitada Shimotohno

1988                      Ph.D., Washington University School of Medicine, USA

                                Topic: Genetics (nematodes), Advisor: Professor Robert H. Waterston

POSITIONS

1989-1998            Assistant Professor, Department of Biology, Kyushu University, Fukuoka,

                                Japan

1998-2004            Associate Professor, Graduate School of Science, Nagoya University, Japan

2004-2023           Professor, Graduate School of Science, Nagoya University, Japan

2014-2023           Unit Leader, Nagoya University Brain Neural Circuit Research Unit

2017-2023            Director, Neuroscience Institute, Graduate School of Science,

                                Nagoya University

2023-                     Senior Research Fellow, Graduate School of Science, Nagoya University

2023-                     Professor Emeritus, Nagoya University

AWARDS

2006                      Saruhashi Award (to a Japanese woman researcher in the natural sciences)

2006                      Inoue Prize for Science (outstanding achievements in basic science)

2013                      Tokizane Award (neuroscience)

2013                       The Kihara Prize (biology)

2016                       Chunichi Cultural Award (cultural contribution in science, humanities, or arts)

2017                       Medal of Honor with Purple Ribbon from Emperor (contribution to society)

2022                       Toray Science and Technology Prize

SELECTED PUBLICATIONS

Professor Mori has >90 publications of which a considerable number are in top journals, including the “big three” (Nature, Science, Cell). Some of those publications are listed here.

(1) I Mori, GM Benian, DG Moerman, RH Waterston (1988) Transposable element Tc1 of Caenorhabditis elegans recognizes specific target sequences for integration. Proceedings of the National Academy of Sciences 85 (3), 861-864

(2) I Mori, Y Ohshima (1995) Neural regulation of thermotaxis in Caenorhabditis elegans. Nature376 (6538), 344-348

(3) H Komatsu, I Mori, JS Rhee, N Akaike, Y Ohshima (1996) Mutations in a cyclic nucleotide–gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17 (4), 707-718

(4) O Hobert, I Mori, Y Yamashita, H Honda, Y Ohshima, Y Liu, G Ruvkun (1997) Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19 (2), 345-357

(5) I Mori (1999) Genetics of Chemotaxis and Thermotaxis in the Nematode Caenorhabditis Elegans. Annual review of genetics 33 (1), 399-422

(6) JS Satterlee, H Sasakura, A Kuhara, M Berkeley, I Mori, P Sengupta (2001) Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx. Neuron 31 (6), 943-956

(7) M Gomez, E De Castro, E Guarin, H Sasakura, A Kuhara, I Mori, T Bartfai, CI Bargmann, P Nef (2001) Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans. Neuron 30 (1), 241-248

(8) A Kuhara, H Inada, I Katsura, I Mori (2002) Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6. Neuron 33 (5), 751-763

(9) T Ishihara, Y Iino, A Mohri, I Mori, K Gengyo-Ando, S Mitani, I Katsura (2002) HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. Cell 109 (5), 639-649

(10) KD Kimura, A Miyawaki, K Matsumoto, I Mori (2004) The C. elegans thermosensory neuron AFD responds to warming. Current Biology 14 (14), 1291-1295

(11) H Sasakura, H Inada, A Kuhara, E Fusaoka, D Takemoto, K Takeuchi, I Mori (2005) Maintenance of neuronal positions in organized ganglia by SAX‐7, a Caenorhabditis elegans homologue of L1. The EMBO journal 24 (7), 1477-1488

(12) Y Okochi, KD Kimura, A Ohta, I Mori (2005) Diverse regulation of sensory signaling by C. elegans nPKC‐epsilon/eta TTX‐4. The EMBO journal 24 (12), 2127-2137

(13) I Mori (2008) A single sensory neuron directs both attractive and repulsive odor preferences. Neuron 59 (6), 839-840

(14) A Kuhara, M Okumura, T Kimata, Y Tanizawa, R Takano, KD Kimura, H Inada, K Matsumoto, I Mori (2008) Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans. Science 320 (5877), 803-807

(15) J Liu, A Ward, J Gao, Y Dong, N Nishio, H Inada, L Kang, Y Yu, D Ma, T Xu, I Mori, Z Xie, XZS Xu (2010) C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog. Nature neuroscience 13 (6), 715-722

(16) N Ohnishi, A Kuhara, F Nakamura, Y Okochi, I Mori (2011) Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans. The EMBO Journal 30 (7), 1376-1388

(17) T Sugi, Y Nishida, I Mori (2011) Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans. Nature neuroscience 14 (8), 984-992

(18) A Kuhara, N Ohnishi, T Shimowada, I Mori (2011) Neural coding in a single sensory neuron controlling opposite seeking behaviours in Caenorhabditis elegans. Nature communications 2 (1), 355

(19) K Kobayashi, S Nakano, M Amano, D Tsuboi, T Nishioka, S Ikeda, G Yokoyama, K Kaibuchi, I Mori (2016) Single-cell memory regulates a neural circuit for sensory behavior. Cell reports 14 (1), 11-21

(20) SWA An, ES Choi, W Hwang, HG Son, JS Yang, K Seo, HJ Nam, NTH Nguyen, EJE Kim, BK Suh, Y Kim, S Nakano, Y Ryu, C Man Ha, I Mori, SK Park, JY Yoo, S Kim, SV Lee (2019) KIN‐4/MAST kinase promotes PTEN‐mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. Aging cell 18 (3), e12906

(21) M Ikeda, S Nakano, AC Giles, L Xu, WS Costa, A Gottschalk, I Mori (2020) Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans. Proceedings of the National Academy of Sciences 117 (11), 6178-6188

(22) S Nakano, M Ikeda, Y Tsukada, X Fei, T Suzuki, Y Niino, R Ahluwalia, A Sano, R Kondo, K Ihara, A Miyawaki, K Hashimoto, T Higashiyama, I Mori (2020) Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans. Proceedings of the National Academy of Sciences 117 (3), 1638-1647

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