Science Portrait: Dr. Yasuhiro Funahashi

This is a Science Portrait of Dr. Yasuhiro Funahashi, Senior Assistant Professor at Fujita Health University. Below shows a summary of the most notable facts of his curriculum vitae (CV).  For additional information of his CV see researchmap or pure.fujita. Dr. Funahashi has kindly agreed to give an ICMS Journal Club presentation next Friday, which I will summarize in this blog later.

                                Curriculum Vitae

Born                      July 9, 1983, in Aichi, Japan

Education           

2007 B.S. in Pharmaceutical Sciences, Department of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

2009 M.S. in Medical Sciences, Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Nagoya, Japan (Prof. Dr. Kozo Kaibuchi)

2014   Ph.D. in Medicine, Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Nagoya, Japan (Prof. Dr. Kozo Kaibuchi)

Work                    

2014-2016            Research fellow, Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Nagoya, Japan

2016-2019            Assistant Professor, Department of Cell Pharmacology, Nagoya University Graduate  School of Medicine, Nagoya, Japan

2020- Present   Senior Assistant Professor, Research Project for Neural and Tumor Signaling, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan

Publications

1. Ariza A*, Funahashi Y* (co-first), Kozawa S, Omar Faruk M, Nagai T, Amano M, Kaibuchi K. Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK. J Neurochem, 2021, 157, 6, 1774-1788, doi: 10.1111/jnc.15303
2. Nagaoka K, Nagashima T, Asaoka N, Yamamoto H, Toda C, Kayanuma G, Siswanto S, Funahashi Y, Kuroda K, Kaibuchi K, Mori Y, Nagayasu K, Shirakawa H, Kaneko S. Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist-induced orofacial dyskinesia. JCI Insight, 2021, 6, 10, e145632. doi: 10.1172/jci.insight.145632
3. Funahashi Y, Watanabe T, Kaibuchi K. Advances in defining signaling networks for the establishment of neuronal polarity. Current opinion in cell biology, 2020, 63, 76-87, doi:10.1016/j.ceb.2019.12.009
4. Funahashi Y, Ariza A, Emi R, Xu Y,Wei S, Suzuki K, Kozawa S, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K. Phosphorylation of Npas4 by MAPK regulates reward-related gene expression and behavior. Cell reports, 2019, 20, 10, doi:3235-3252.e9, 10.1016/j.celrep.2019.10.116
5. Nishino T, Tamada K, Maeda A, Abe T, Kiyonari H, Funahashi Y, Kaibuchi K, Takumi T, Konishi H. Behavioral alterations in mice deficient for a brain specific GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2). Molecular Brain, 2019, 12, 1,94, doi: 10.1186/s13041-019-0512-x
6. Takano T, Funahashi Y, Kaibuchi K. Neuronal Polarity: Positive and Negative Feedback Signals. Frontiers in Cell and Developmental Biology, 2019, 7, 69, doi: 10.3389/fcell.2019.00069
7. Nishioka T, Amano M, Funahashi Y, Tsuboi D, Yamahashi Y, Kaibuchi K. In Vivo Identification of Protein Kinase Substrates by Kinase-Oriented Substrate Screening (KIOSS). Current protocols in chemical biology, 2019, 11, 1, e60, doi: 10.1002/cpch.60
8. Zhang X, Nagai T, Ahammad RU, Kuroda K, Nakamuta S, Nakano T, Yukinawa N, Funahashi Y, Yamahashi Y, Amano M, Yoshimoto J, Yamada K, Kaibuchi K. Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons. Neurochemistry International, 2019, 122, 8-18, doi: 10.1016/j.neuint.2018.10.008
9. Amano M, Nishioka T, Tsuboi D, Kuroda K, Funahashi Y, Yamahashi Y, Kaibuchi K. Comprehensive analysis of kinase-oriented phospho-signaling pathways. The Journal of Biochemistry, 2018, 165, 4, 301-307, doi: 10.1093/jb/mvy115
10. Yura Y, Amano M, Takefuji M, Bando T, Suzuki K, Kato K, Hamaguchi T, Hasanuzzaman Shohag M, Takano T, Funahashi Y, Nakamuta S, Kuroda K, Nishioka T, Murohara T, Kaibuchi K. Focused Proteomics Revealed a Novel Rho-kinase Signaling Pathway in the Hear. Cell Structure and Function, 2016, 41, 2, 105-120, doi: 10.1247/csf.16011
11. Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K. Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo. Neuron, 2016, 39, 3, 550-565, doi: 10.1016/j.neuron.2015.12.019
12. Xu C, Funahashi Y, Watanabe T, Takano T, Nakamuta S, Namba T, Kaibuchi K. Radial glial cell-neuron interaction directs axon formation at the opposite side of the neuron from the contact site. The Journal of Neuroscience, 2015, 35, 43, doi: 10.1523/JNEUROSCI.1266-15.20
13. Hamaguchi T, Nakamuta S, Funahashi Y, Takano T, Nishioka T, Shohag MH, Yura Y, Kaibuchi K, Amano M. In vivo screening for substrates of protein kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity. Cell Structure and Function, 2015, 40, 1, 1-12, doi: 10.1247/csf.14014
14. Namba T, Funahashi Y, Nakamuta S, Xu C, Takano T, Kaibuchi K. Extracellular and Intracellular Signaling for Neuronal Polarity. Physiological Reviews, 2015, 95, 3, 995-1024, doi: 10.1152/physrev.00025.2014
15. Takano T, Xu C, Funahashi Y, Namba T, Kaibuchi K. Neuronal polarization. Development, 2015, 142, 12, 2088-2093, doi: 10.1242/dev.114454
16. Namba T, Kibe Y, Funahashi Y, Nakamuta S, Takano T, Ueno T, Shimada A, Kozawa S, Okamoto M, Shimoda Y, Oda K, Wada Y, Masuda T, Sakakibara A, Igarashi M, Miyata T, Faivre-Sarrailh C, Takeuchi K, Kaibuchi K. Pioneering axons regulate neuronal polarization in the developing cerebral cortex. Neuron, 2014, 81, 4, 814-829, doi: 10.1016/j.neuron.2013.12.015
17. Funahashi Y, Namba T, Nakamuta S, Kaibuchi K. Neuronal polarization in vivo: Growing in a complex environment. Current Opinion in Neurobiology, 2014, 27, 215-223, doi: 10.1016/j.conb.2014.04.009
18. Funahashi Y, Namba T, Fujisue S, Itoh N, Nakamuta S, Kato K, Shimada A, Xu C, Shan W, Nishioka T, Kaibuchi K. ERK2-mediated phosphorylation of Par3 regulates neuronal polarization. The Journal of Neuroscience, 2013, 33, 33, 13270-13285 doi: 10.1523/JNEUROSCI.4210-12.2013
19. Nakamuta S, Funahashi Y, Namba T, Arimura N, Picciotto MR, Tokumitsu H, Soderling TR, Sakakibara A, Miyata T, Kamiguchi H, Kaibuchi K. Local application of neurotrophins specifies axon through inositol 1, 4, 5-trisphosphate. Science Signaling, 2011, 4, 119, ra76, doi: 10.1126/scisignal.2002011
20. Namba T, Nakamuta S, Funahashi Y, Kaibuchi K. The role of selective transport in neuronal polarization. Developmental Neurobiology, 2011, 71, 6, 445-457, doi:10.1002/dneu.20876
21. Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A, Ménager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K. Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Developmental Cell, 2009, 16, 5, 675-686, doi: 10.1016/j.devcel.2009.03.005
22. Arimura N, Hattori A, Kimura T, Nakamuta S, Funahashi Y, Hirotsune S, Furuta K, Urano T, Toyoshima YY, Kaibuchi K. CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. Journal of neurochemistry, 2009, 111, 2, 380-390, doi: 10.1111/j.1471-4159.2009.06317.x