Science Portrait: Prof. Eleonora Leucci

Although still young, Prof. Leucci has established quite a name for herself in the field of noncoding RNAs and cancer. Transcripts and cancer have been the major research themes throughout her career. She got her Ph.D. at the University of Siena, Italy, for studying miRNA function in Burkitt Lymphoma pathogenesis. After continuing for a short time as research assistant in Siena, she did a postdoc at the University of Copenhagen, Denmark, again on miRNA, but now in relation to Hodgkin Lymphoma and the expression of the long noncoding (lnc) RNA called MALAT1. Then she did a postdoc at the VIB (Vlaams Instituut voor Biotechnologie) in Leuven, Belgium, where she found that most melanomas specifically express and are actively supported by — even depend on [!] — an lncRNA called SAMMSON, which was published in Nature (Leucci et al. 2016). This Nature paper can probably be considered as the breakthrough moment of her career. She then in 2017 could start her own group, the Laboratory for RNA Cancer Biology, at KU (Katholieke Universiteit) Leuven, and is still running this group to date. The group is researching a variety of cancers, but melanoma research stays important, and among RNAs a major focus of theirs remains on noncoding RNAs. Since that first Nature paper in 2016, Prof. Leucci has kept publishing in top-journals including Nature, Nature Medicine, Journal of Experimental Medicine, Cancer Cell (2x), Nature Genetics, Nature Cancer, Nature Structural and Molecular Biology, and Nucleic Acids Research.

Prof. Leucci is not just an RNA specialist but also an expert in patient-derived xenograft (PDX) mouse models (patient tumors can be grown in immunodeficient mice to study their properties), and as Head of Trace PDX Platform at KU Leuven she represents the Belgium branch of EuroPDX. In this function, in Leuven, Prof. Leucci oversees >150 PDX models belonging to ten different types of cancer. The EuroPDX consortium provides some services for—and samples of—PDX models to the international community.

I am very glad and honored that she will give a presentation at Fujita Health University. Not only will we learn about noncoding RNAs in cancer from one of the worldwide experts in this field, but we will also learn about the PDX models in the EuroPDX consortium.

I don’t know her very well, but from a congress I remember her as a kind person with interesting opinions, who somehow seems immune to the competition virus. Her kindness shows by the fact that even previously, when our Seminar Club was smaller and just at the institute level, she had already agreed to give a presentation. When I asked her if she could write something personal about her science for this blog, such as what drives her, she wrote these beautiful sentences:

My Science

(a personal statement about her science by Professor Leucci for this blog; the links were added by me as the Japanese audience may be less familiar with European literature and mythology)

Regarding my science: I see science as a never-ending travel beyond Hercules Pillars, it is what keeps me alive. My favourite quotes are

Alfred Tennyson (1809-1892): Ulysses

Much have I seen and known; cities of men

And manners, climates, councils, governments,

Myself not least, but honour’d of them all;

And drunk delight of battle with my peers,

Far on the ringing plains of windy Troy.

I am a part of all that I have met;

and also

Dante (1265-1321): Inferno, canto XXVI

Fatti non foste a viver come bruti ma per seguire virtute e canoscenza

[In English: “You weren’t made to live like brutes but to acquire virtue and knowledge”]

 

CURRICULUM VITAE

 

EDUCATION:

2003                     MSc in Molecular Biology, Summa Cum Laude, University of Siena, Italy.

                              Thesis title: Role of the transcription factor PROX1 in lymphangiogenesis

2007                     PhD in Medical Biotechnology, University of Siena.

                              Thesis Title: Role of miRNAs and genetic alterations other than MYC in

                              Lymphomagenesis.

 

PROFESSIONAL EXPERIENCE:

2007-2008          Research assistant, Department of Human Pathology and Oncology, University

                               of Siena, Italy:     

                                    – miRNAs in Burkitt Lymphoma pathogenesis

2008-2012           Postdoctoral fellow, BRIC, University of Copenhagen, Denmark:

                                   – miRNA target identification

                                   – Role of miR-9 in Hodgkin Lymphoma development

2012-2016          Postdoctoral fellow, VIB-KU Leuven, Belgium:

                                    – LncRNA in skin cancer

2016-2017          Research Associate FNRS, ULB, Belgium.

2017-current      Head of TRACE (KU Leuven PDX platform) KU Leuven, Belgium.

2017-current      Research professor and independent PI: Laboratory for RNA Cancer Biology,

                                 KU Leuven,　Belgium:

                                    – LncRNAs in cancer

 

REVIEWER AND EDITOR FUNCTIONS:

Reviewer for Oncogene, NAR, Nature Cancer, Molecular Cancer, Cell death and disease, PCMR, Cell report, EMBO reports, Trends in Genetics, Nature Review Cancer, Cancer Research, eLife, Nat Comm, and more

Reviewer for INSERM, INCa and Plancancer, ATIP (France), EU, New Zealand cancer society, Israel Science Foundation, Netherlands Organization for Scientific Research, DGI UDLA (Ecuador), MIUR and AIFA (Italy), Virchow 2.0 (Germany), FWF Austrian Science Fund

Editor of Cell Stress and NcRNA Journal

 

INSTITUTIONAL RESPONSIBILITIES:

Since 2017         Member of the Council of the Faculty of Medicine.

Since 2017         Member of the Council of the Department of Oncology.

Since 2017         Full member of the EuroPDX consortium

 

ORGANIZER OF COURSES AND CONFERENCES:

Dec 2020          “Liquid-Liquid phase separation” VIB, Leuven, Belgium.

May 2019          11th European Melanoma Workshop. Otranto (Italy).

May 2016          Leuven (Belgium): “The non-coding Genome”.

 

HONORS AND GRANTS:

2003-2007          The Ministry of Education, University and Research PhD fellowship.

2008                     The Journal of Pathology Jeremy Jass Prize highly commended paper

2009-2012          FSS (The Danish council for independent research) postdoctoral grant.

2013-2016          OMICS@VIB: VIB/Marie Curie postdoctoral fellowship.

2016                     The Royal academy of Belgium: Award of the Academy of

                               fundamental scientific research in Medicine.

2016                    ITWIIN The Italian Association of Women Inventors and Innovators. Special

                               mention: Italian woman abroad.

2017                     KU Leuven starting grant: “Role of ncRNA in translation reprogramming”

2017                     Fund Emile Carpentier/ André Vander Stricht/ Van Damme. King Baudouin

                               foundation.

2018                    Kom op tegen Kanker: “Treating melanoma as an infectious disease”.

2018                    Melanoma Research Alliance (MRA) young investigator award.

2018                     Stichting tegen Kanker: “Exploiting lncRNAs to drug the undruggable in

                               BRAFWT melanoma”.

2019 FWO-KOTK   “Overcoming melanoma resistance to TT and immune checkpoint

                                  inhibitors”.

2019 FWO            Role of MrT in cutaneous melanoma.

 

PUBLICATIONS

1. De Falco, G., Bellan, C., D’Amuri, A., Angeloni, G., Leucci, E., Giordano, A., Leoncini, L. Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors (2005) Cancer Biology and Therapy, 4 (3), pp. 277-281.

2. Florio, P., Torricelli, M., Galleri, L., De Falco, G., Leucci, E., Calonaci, G., Picciolini, E., Ambrosini, G., Linton, E.A., Petraglia, F. High fetal urocortin levels at term and preterm labor (2005) Journal of Clinical Endocrinology and Metabolism, 90 (9), pp. 5361-5365.

3. Florio, P., De Falco, G., Leucci, E., Torricelli, M., Torres, P.B., Toti, P., Dell’Anna, A., Tiso, E., Santopietro, R., Leoncini, L., Petraglia, F. Urocortin expression is downregulated in human endometrial carcinoma (2006) Journal of Endocrinology, 190 (1), pp. 99-105.

4. Nyagol, J., Leucci, E., Onnis, A., De Falco, G., Tigli, C., Sanseverino, F., Torriccelli, M., Palummo, N., Pacenti, L., Santopietro, R., Spina, D., Gichangi, P., Muchiri, L., Lazzi, S., Petraglia, F., Leoncini, L., Giordano, A. The effects of HIV-1 tat protein on cell cycle during cervical carcinogenesis (2006) Cancer Biology and Therapy, 5 (6), pp. 684-690.

5. Florio, P., Torricelli, M., De Falco, G., Leucci, E., Giovannelli, A., Gazzolo, D., Severi, F.M., Bagnoli, F., Leoncini, L., Linton, E.A., Petraglia, F. High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension (2006) Journal of Hypertension, 24 (9), pp. 1831-1840.

6. Torricelli, M., De Falco, G., Florio, P., Rossi, M., Leucci, E., Viganò, P., Leoncini, L., Petraglia, F. Secretory endometrium highly expresses urocortin messenger RNA and peptide: Possible role in the decidualization process (2007) Human Reproduction, 22 (1), pp. 92-96.

7. Torricelli, M., Giovannelli, A., Leucci, E., De Falco, G., Reis, F.M., Imperatore, A., Florio, P., Petraglia, F. Labor (term and preterm) is associated with changes in the placental mRNA expression of corticotrophin-releasing factor (2007) Reproductive Sciences, 14 (3), pp. 241-245.

8. Leucci, E., Onnis, A., De Falco, G., Luzzi, A., Cerino, G., Giordano, A., Leoncini, L. Silencing human Rb2/p130 with shRNA (2007) Cellular Oncology, 29 (3), pp. 265-268. DOCUMENT TYPE: Letter.

9. Leucci, E., De Falco, G., Onnis, A., Cerino, G., Cocco, M., Luzzi, A., Crupi, D., Tigli, C., Bellan, C., Tosi, P., Leoncini, L., Giordano, A. The role of the Cdk9/cyclin T1 complex in T cell differentiation (2007) Journal of Cellular Physiology, 212 (2), pp. 411-415.

10. De Falco, G., Leucci, E., Lenze, D., Piccaluga, P.P., Claudio, P.P., Onnis, A., Cerino, G., Nyagol, J., Mwanda, W., Bellan, C., Hummel, M., Pileri, S., Tosi, P., Stein, H., Giordano, A., Leoncini, L. Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors (2007) Blood, 110 (4), pp. 1301-1307.

11. Bardelli, M.,* Leucci, E.*, Schürfeld, K., Bellan, C., Passiatore, G., Rocchigiani, M., Bartolommei, S., Orlandini, M., Zagursky, J., Lazzi, S., De Falco, G., Tosi, P., Oliviero, S., Leoncini, L. VEGF-D is expressed in activated lymphoid cells and in tumors of hematopoietic and lymphoid tissues (2007) Leukemia and Lymphoma, 48 (10), pp. 2014-2021.

12. Torricelli, M., Giovannelli, A., Leucci, E., Florio, P., De Falco, G., Torres, P.B., Reis, F.M., Leoncini, L., Petraglia, F. Placental Neurokinin B mRNA Expression Increases at Preterm Labor (2007) Placenta, 28 (10), pp. 1020-1023.

13. De Falco, G., Leucci, E., Onnis, A., Bellan, C., Tigli, C., Wirths, S., Cerino, G., Cocco, M., Crupi, D., De Luca, A., Lanzavecchia, A., Tosi, P., Leoncini, L., Giordano, A. Cdk9/Cyclin T1 complex: A key player during the activation/differentiation process of normal lymphoid B cells (2008) Journal of Cellular Physiology, 215 (1), pp. 276-282.

14. Leucci, E., Cocco, M., Onnis, A., De Falco, G., Van Cleef, P., Bellan, C., Van Rijk, A., Nyagol, J., Byakika, B., Lazzi, S., Tosi, P., Van Krieken, H., Leoncini, L. MYC translocation-negative classical Burkitt lymphoma cases: An alternative pathogenetic mechanism involving miRNA deregulation (2008) Journal of Pathology, 216 (4), pp. 440-450.

15. Leucci, E., Onnis, A., Cocco, M., De Falco, G., Imperatore, F., Giuseppina, A., Costanzo, V., Cerino, G., Mannucci, S., Cantisani, R., Nyagol, J., Mwanda, W., Iriso, R., Owang, M., Schurfeld, K., Bellan, C., Lazzi, S., Leoncini, L. B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression (2010) International Journal of Cancer, 126 (6), pp. 1316-1326.

16. Christoffersen, N.R., Shalgi, R.*, Frankel, L.B.*, Leucci, E., Lees, M., Klausen, M., Pilpel, Y., Nielsen, F.C., Oren, M., Lund, A.H. P53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC (2010) Cell Death and Differentiation, 17 (2), pp. 236-245.

17. Wynendaele, J., Böhnke, A., Leucci, E., Nielsen, S.J., Lambertz, I., Hammer, S., Sbrzesny, N., Kubitza, D., Wolf, A., Gradhand, E., Balschun, K., Braicu, I., Sehouli, J., Darb-Esfahani, S., Denkert, C., Thomssen, C., Hauptmann, S., Lund, A., Marine, J.-C., Bartel, F. An illegitimate microRNA target site within the 3′ UTR of MDM4 affects ovarian cancer progression and chemosensitivity (2010) Cancer Research, 70 (23), pp. 9641-9649.

18. Piccaluga, P.P., De Falco, G., Kustagi, M., Gazzola, A., Agostinelli, C., Tripodo, C., Leucci, E., Onnis, A., Astolfi, A., Sapienza, M.R., Bellan, C., Lazzi, S., Tumwine, L., Mawanda, M., Ogwang, M., Calbi, V., Formica, S., Califano, A., Pileri, S.A., Leoncini, L. Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes (2011) Blood, 117 (13), pp. 3596-3608.

19. Leucci, E., Zriwil, A., Gregersen, L.H., Jensen, K.T., Obad, S., Bellan, C., Leoncini, L., Kauppinen, S., Lund, A.H. Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo (2012) Oncogene, 31 (49), pp. 5081-5089.

20. Patella, F., Leucci, E., Evangelista, M., Parker, B., Wen, J., Mercatanti, A., Rizzo, M., Chiavacci, E., Lund, A.H., Rainaldi, G. MiR-492 impairs the angiogenic potential of endothelial cells (2013) Journal of Cellular and Molecular Medicine, 17 (8), pp. 1006-1015. DOI: 10.1111/jcmm.12085.

21. Leucci, E., Patella, F., Waage, J., Holmstrøm, K., Lindow, M., Porse, B., Kauppinen, S., Lund, A.H. MicroRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus (2013) Scientific Reports, 3, art. no. 2535. DOI: 10.1038/srep02535.

22. Wen, J.*, Leucci, E.*, Vendramin, R., Kauppinen, S., Lund, A.H., Krogh, A., Parker, B.J. Transcriptome dynamics of the microRNA inhibition response (2015) Nucleic Acids Research, 43 (13), pp. 6207-6221.

23. Leucci, E., Vendramin, R., Spinazzi, M., Laurette, P., Fiers, M., Wouters, J., Radaelli, E., Eyckerman, S., Leonelli, C., Vanderheyden, K., Rogiers, A., Hermans, E., Baatsen, P., Aerts, S., Amant, F., Van Aelst, S., Van Den Oord, J., De Strooper, B., Davidson, I., Lafontaine, D.L.J., Gevaert, K., Vandesompele, J., Mestdagh, P., Marine, J.-C. Melanoma addiction to the long non-coding RNA SAMMSON (2016) Nature, 531 (7595), pp. 518-522.

24. Adriaens, C.*, Standaert, L.*, Barra, J., Latil, M., Verfaillie, A., Kalev, P., Boeckx, B., Wijnhoven, P.W.G., Radaelli, E., Vermi, W., Leucci, E., Lapouge, G., Beck, B., Van Den Oord, J., Nakagawa, S., Hirose, T., Sablina, A.A., Lambrechts, D., Aerts, S., Blanpain, C., Marine, J.-C. P53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity (2016) Nature Medicine, 22 (8), pp. 861-868. DOI: 10.1038/nm.4135. DOCUMENT TYPE: Article.

25. Leucci, E., Coe, E.A., Marine, J.-C., Vance, K.W. The emerging role of long non-coding RNAs in cutaneous melanoma (2016) Pigment Cell and Melanoma Research, 29 (6), pp. 619-626.

26. Vendramin R., Marine J-C., Leucci E. LncRNA: the dark side of nuclear-mitochondrial communication (2017) The EMBO Journal 36 (9), pp. 1123-1133.

27. Leucci, E., Close, P., Marine, J.C. Translation rewiring at the heart of phenotype switching in melanoma (2017) Pigment Cell and Melanoma Research, 30 (3), pp. 282-283.

28. Barra, J., Leucci, E. Probing long non-coding RNA-protein interactions (2017) Frontiers in Molecular Biosciences 4, pp. 45.

29. Leucci, E. Escaping BRAF inhibition: A “linc” with non-coding RNAs? (2018) Pigment Cell and Melanoma Research 31 (2), pp. 236-237.

30. Leucci, E. Cancer development and therapy resistance: spotlights on the dark side of the genome (2018) Pharmacology & Therapeutics 189, pp. 22-30

31. Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., de Tullio, P., Sin, O., Schmitz, S., Piepers, J., Ghesquière, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., Rorive, R., Jerusalem, G., Leucci, E., et al. Codon-specific translation reprogramming promotes resistance to targeted therapy (2018) Nature 558 (7711), pp. 605-609.

32. Verheyden, Y., Goedert, L., Leucci, E. Control of nucleolar stress and translational reprogramming by lncRNAs (2018) Cell Stress 3 (1), pp. 19-26.

33. De Troyer, L., Zhao, P., Pastor, T., Baietti, M.F., Barra, J., Vendramin, R., Dok, R., Lechat, B., Najm, P., Van Haver, D., Impens, F., Leucci, E., Sablina, A.A. Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3 (2020) Nucleic Acids Research 48 (5), pp. 2502-2517.

34. Vendramin, R., Verheyden, Y., Ishikawa, H., Goedert, L., Nicolas, E., Saraf, K., Armaos, A., Delli Ponti, R., Izumikawa, K., Mestdagh, P., Lafontaine, D.L.J., Tartaglia, G.G., Takahashi, N., Marine, J.C., Leucci, E. SAMMSON fosters cancer cell fitness by enhancing concertedly mitochondrial and cytosolic translation. (2018) Nature Structural and Molecular Biology 25(11), pp. 1035-1046.

35. Girard, C.A., Lecacheur, M., Ben Jouira, R., Berestjuk, I., Diazzi, S., Prod’homme, V., Mallavialle, A., Larbret, F., Gesson, M., Schaub, S., Pisano, S., Audebert, S., Mari, B., Gaggioli, C., Leucci, E., Marine, J.C., Deckert, M., Tartare-Deckert, S. A feed-forward mechanosignaling loop confers resistance to therapies targeting the MAPK pathway in BRAF mutant melanoma. (2020) Cancer Research 80 (10), pp. 1927-1941.

36. Barra, J., Gaidosh, G.S., Blumenthal, E., Beckedorff, F., Tayari, M.M., Kirstein, N., Karakach, T.K., Jensen, T.H., Impens, F., Gevaert, K., Leucci, E.#, Shiekhattar, R.# , Marine, J.C.#. Integrator restrains paraspeckles assembly by promoting the 3’-end processing of the polyadenylated lncRNA NEAT1_1. Science advances. Science Advances Vol. 6, No. 27. DOI: 10.1126/sciadv.aaz9072.

37. Thomas, A., Vanthoor, J., Himmelreich, U., Cawtthorne, C., Deroose, C., Gsell, W., Spans, L., Rizzotto, L., Leucci, E., Van Rompuy, A.S., Muneer, A., Albersen, M. Establishment, Characterization, and Imaging of a First Platinum-resistant Penile Cancer Patient-derived Xenograft in Nude Mice: A eUROGEN Project (2020) European Urology 78 (2), pp. 294-296.

38. Aprile, M.*, Katopodi, V.*, Leucci, E.#, Costa, V.#. LncRNAs in Cancer: From garbage to Junk (2020) Cancers (Basel) 12 (11), pp. E3220.

39. Koval, A., Bassanini, I., Xu, J., Tonelli, M., Boido, V., Sparatore, F., Amant, F., Annibali, D., Leucci, E., Sparatore, A., Katanaev, V.L. Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo (2021) European Journal of Medicinal Chemistry 222, pp. 113562.

40. Jeschke, J., Collignon, E., Al Wardi, C., Krayem, M., Bizet, M., Jia, Y., Garaud, S., Wimana, Z., Calonne, E., Hassabi, B., Morandini, R., Deplus, R., Putmans, P., Dube, G., Singh, N., Koch, A., Shostak, K., Rizzotto, L., Ross, R.L., Desmedt, C., Bareche, Y., Rothe, F., Lehmann-Che, J., Duterque-Coquillaud, M., Leroy, X., Menschaert, G., Teixeira, L., Guo, M., Limbach, P.A., Close, P., Chariot, A., Leucci, E., Ghanem, G., Yuan, B.F., Willard-Gallo, K., Sotiriou, C., Marine, J.C., Fuks, F. Downregulation of the m6A RNA demethylase FTO in epithelial cancers promotes EMT-mediated tumor progression and confers sensitivity to Wnt inhibitors (2021) Nature Cancer 2, pp. 611–628.

41. Melixetian, M., Bossi, D., Mihailovic, M., Punzi, S., Barozzi, I., Cuomo, A., Bonaldi, T., Marine, J.C., Leucci, E., Minucci, S., Pelicci, P.G., Lanfrancone, L (2021) EMBO Reports 2 (3), pp. e50852.

42. Woo, X.Y., et al.; PDXNET Consortium; EurOPDX Consortium. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts (2021) Nature Genetics 53 (1), pp. 86-99.

43. Patton, E.E., Mueller, K.L., Adams, D.J., Anandasabapathy, N., Aplin, A.E., Bertolotto, C., Bosenberg, M., Ceol, C.J, Chi, P., Herlyn, M., Holmen, S.L., Karreth, F.A., Kaufman, C.K., Khan, S., Kobold, S., Leucci, E., Levy, C., Lombard, D.B., Lund, A.W., Marie, K.L., Marine, J.C., Marais, R., McMahon, M., Robles-Espinoza, C.D., Ronai, Z.A., Samuels, Y., Soengas, M.S., Villanueva, J., Weeraratna, A.T., White, R.M., Yeh, I., Zhu, J., Zon, L.I., Hurlbert, M.S., Merlino, G. Melanoma models for the next generation of therapies (2021) Cancer Cell 39 (5), 610-631.

44. Marin-Bejar, O., Rogiers, A., Dewaele, M., Femel, J., Karras, P., Pozniak, J., Bervoets, G., Van Raemdonck, N., Pedri, D., Demeulemeester, J., Vander Borght, S., Bosisio, F., van den Oord, J., Vanden Bempt, I., Lambrechts, D., Voet, T., Bechter, O., Leucci, E., Lund, A.W., Rambow, F., Marine, J.C.. Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs (2021) Cancer Cell 39 (8), pp. 1135-1149.

45. Vendramin, R., Katopodi, K., Cinque, S., Konnova, A., Knezevic, Z., Adnane, S., Verheyden, Y., Karras, P., Demesmaeker, E., Bosisio, F.M., Kucera, L., Rozman, J., Gladwyn-Ng, I., Rizzotto, L., Dassi, E., Millevoi, S., Bechter, O., Marine, J.C.*, Leucci, E*. Activation of the Integrated Stress Response confers vulnerability to mitoribosome-targeting antibiotics in melanoma (2021) Journal of Experimental Medicine 218(9), pp. e20210571.

46. Dewaele, S., Delhaye, L., De Paepe, B., de Bony, E.J., De Wilde, J., Vanderheyden, K., Anckaert, J., Yigit, N., Nuytens, J., Vanden Eynde, E., Smet, J., Verschoore, M., Nemati, F., Decaudin, D., Rodrigues, M., Zhao, P., Jochemsen, A., Leucci, E., Vandesompele, J., Van Dorpe, J., Marine, J.C., Van Coster, R., Eyckerman, S., Mestdagh, P. The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival (2022) Oncogene 41 (1), pp. 15-25.

47. Adnane, S., Marino, A., Leucci, E. LncRNAs in cancer: signal from noise (2022) Trends in Cell Biology Feb 12;S0962-8924(22)00007-1. doi: 10.1016/j.tcb.2022.01.006. Online ahead of print.

Book chapters

1. M(R)apping RNA-protein interactions. Methods Mol Biol. 2021;2254:259-272. doi: 10.1007/978-1-0716- 1158-6_16.

2. Development of patient-derived tumour xenograft models. Methods Mol Biol. 2019;1862:217-225. doi: 10.1007/978-1-4939-8769-6_15.

3. Long Noncoding RNA as Novel Cancer Diagnostic and Effective Therapeutic Targets. In Applied RNA Bioscience Springer Nature. DOI: 10.1007/978-981-10-8372-3.